Rhizoma Ligustici Chuanxiong is one of the well-known medicinal materials located in Sichuan origin.It is a traditional Chinese herbal medicine commonly used in clinic with a long history of cultivation.However,some problems still exist in the production of Rhizoma Ligustici Chuanxiong,such as blind introduction and non-standard breeding of Rhizoma Ligustici Chuanxiong,serious diseases and pests.Especially,the problem of pesticide residue and cadmium exceeding the standard have not been effectively solved,which seriously affects the sustainable development of Rhizoma Ligustici Chuanxiong industry.The effective way to ensure the sustainable development of Rhizoma Ligustici Chuanxiong industry is to carry out the research of pollution-free cultivation technology,and it is also a developing direction for the production of traditional Chinese medicine at present.Based on the production data of base and combind with the successful experience of other bases in China and literature investigation,this paper showed the pollution-free cultivation technology system of Rhizoma Ligustici Chuanxiong.The system includes site selection base on GIS (Geographic Information System) technology,comprehensive soil improvement,breeding of improved varieties,rational fertilization,integrated control of diseases and pests,etc.It can provide a new way to solve the problem of excessive cadmium and scientifically guide the cultivation of Rhizoma Ligustici Chuanxiong without pollution,improve the quality,and promote the sustainable development of Rhizoma Ligustici Chuanxiong industry.