Scutellaria baicalensis is used as one of common herbs in Traditional Chinese Medicine.At present,the wildlife resource of Scutellaria baicalensis is decreasing significantly,the quality of Scutellaria baicalensis herbs is too varying resulting from the difference in germplasm,origins,cultivation methods,and plant diseases/insect pests are more serious in fields.Building pollution-free cultivation technology of Scutellaria baicalensis is an effective method to solve these problems.Based on ecological factors value of 403 geographical points of Scutellaria baicalensis,this paper calculated the most suitable value by Global Geographic Information System for Medicinal Plant (GMPGIS) to guide introduction and expansion.This paper also combined the technology of breeding,field management,application of fertilizer and pesticides,and biological control agents to supply reference for pollution-free cultivation of Scutellaria baicalensis,and excellent germplasm resources and high-quality medical materials for agricultural production and clinical application