To analyze and discover the curative effects and safety of Yiqi Huoxue Decoction combined with Western drugs.Methods:Clinical observations were based on multi-center,random,double-blind,and parallel controlled trial.A total of 62 patients were randomly divided into the observation group and control group with inclusion criteria from January 2012 to February 2014,which were under one course of treatment (30 days).The observation group was treated with Yiqi Huoxue Decotion combined with western drugs,while the control observation was treated with western drugs and herbal placebo.The abdominal perimeter,body weight,urinary volume in 24 hours,ascites volume,liver function,coagulation function,intellectuality level,the variation of symptom scores in traditional Chinese medicine were recorded in the course.Results:The observation group had better effects in diuresis facet according to the average body weight,abdominal perimeter,and urinary volume.There was statistical difference in ascites in the two groups tested in right lateral position (P<0.01).The control group of liver function between the two groups showed no statistical difference,but the index of the observation group improved than those in control group.There was no statistical difference in the intellectuality level between the two groups with shortened time in NCT-A,DST experiments.The variation of symptom score,such as pain in abdomen,abdominal distention,poor appetite,tiredness,lassitude and disinclination to talk,had a statistical difference (P<0.01).The safety of Yiqi Huoxue Decoction was without statistic difference.Conclusion:1)The combined therapy of Yiqi Huoxue Decoction and Western drugs has advantages in diuresis and relieve ascites.2)As there is no significant difference between two groups,but the tendency of liver function indicates synergistic effects in liver function among the specific period.3)There is potential advantage of Yiqi Huoxue Decoction in improving the liver function.4)The decoction is safe to some extent. |