To explore the effects of Bunao Xifeng Zhijing Decoction on the serum inflammatory factors of Parkinson's disease patients.Methods:A total of 69 cases Parkinson's disease patients were selected and divided randomly into control group (n=34) and observation group (n=35) in Sichuan Provincial People's Hospital from March 2017 to April 2018.The control group was treated with levodopa,and the observation group was treated levodopa with Bunao Xifeng Zhijing Decoction on the basis of control group.The 2 groups were treated continuously 2 months.The UPDRS (Unified Parkinson's Disease Rating Scale) scores and Chinese medicine syndrome points in 2 groups before and after treatment were compared.The clinical efficacy in 2 groups were accumulated.The changes of cognitive function and serum inflammatory factors of 2 groups were detected and compared.Results:Compared with before treatment,the UPDRS-Ⅰ,UPDRS-Ⅱ,UPDRS-Ⅲ,UPDRS-Ⅳ scores in 2 groups and the Chinese medicine syndrome point in observation group decreased after treatment,and observation group was lower compared with control group (P<0.05 or P<0.01).The clinical efficacy rate in observation group after treatment reached up to 88.57%,which significantly increased than that 67.65% in control group (P<0.05).Compared with before treatment,the MMSE (Mini-Mental State Examination),MoCA (Montreal Cognitive Assessment) scores in 2 groups and serum SOD level in observation group increased after treatment,and observation group was higher compared with control group (P<0.05 or P<0.01).The serum IL-6,IL-1β,MDA levels in 2 groups decreased,and observation group was lower than control group (P<0.05 or P<0.01).Conclusion:Bunao Xifeng Zhijing Decoction can improve the clinical symptom of Parkinson's disease patients,reduce the serum inflammatory factors level,inhibit the oxidative stress and enhance the cognitive function of patients.The clinical efficacy is superior to conventional western medicine remarkably.