To observe the effects of Kuhuang Injection combined with magnesium isoglycyrrhizinate on symptoms improvement，serum inflammatory factors，alanine aminotransferase (ALT)，total bilirubin (TBIL) and direct bilirubin (DBIL) levels in patients with acute jaundice viral hepatitis.Methods:A total of 180 patients with acute jaundice viral hepatitis treated in the Eighth Hospital of Xi'an City from January 2014 to January 2017 were selected and randomly divided into control group and observation group，each with 90 cases.The control group was treated with magnesium isoglycyrrhizinate，and 90 cases in the observation group were treated with Kuhuang Injection combined with magnesium isoglycyrrhizinate.Both the two groups were treated for 2 weeks.The clinical efficacy after treatment was compared between the two groups.Symptomatic improvement was recorded before and after treatment in the 2 groups.The levels of serum inflammatory factors，liver function indexes and oxidative stress were detected before and after treatment in the 2 groups.Results:After treatment，the total effective rate of the observation group was significantly higher than that of control group (P<0.05).The traditional Chinese medicine (TCM) symptom score，serum interleukin-6 (IL-6)，tumor necrosis factor alpha (TNF-α) and high sensitive C reactive protein (hs-CRP)，ALT，TBIL，DBIL levels and malondialdehyde (MDA) content of the 2 groups after treatment were significantly decreased than before treatment (P<0.05)，and the decreasing degree of above indexes in observation group was superior to those in the control group (P<0.05).The activity of superoxide dismutase (SOD) in both groups was significantly increased after treatment (P<0.05)，and it in the observation group was increased more significantly than that in the control group.Conclusion:Kuhuang Injection combined with magnesium isoglycyrrhizinate in the treatment of acute jaundice viral hepatitis can obviously improve the symptoms，reduce the levels of serum inflammatory factors and liver function indexes.