To observe the effects of modified Sijunzi Decoction on anti helicobacter pylori (HP) in the treatment of non-erosive reflux disease (NERD) in patients with spleen and stomach weakness.Methods:A total of 90 cases with NERD with spleen and stomach weakness and HP positive who were admitted and treated in our hospital from July 2015 to February 2017 were randomly selected and divided into treatment group and control group according to random number table, with 45 cases in each group.The control group was treated with HP triple therapy plus gastric motility drug.The treatment group was added with oral administration of Sijunzi decoction.The improvement of symptom integral, clinical efficacy and the negative rate of HP were analyzed before treatment and 6 weeks after treatment.And the changes of esophageal mucosa cells under electron microscope were observed.Results:After 6 weeks, the total effective rate of treatment group (95.55%) was better than the control group (84.44%) (P<0.05); Symptom integral Sc value of two groups were significantly decreased (P<0.05), and the treatment group was significantly better than the control group (P<0.05).A total of 41 cases in the treatment group were negative, with negative rate of 91.11%, 37 cases in the control group with 82.22% of negative rate.The negative rate of treatment group was significantly better than the control group (P<0.05).The electron microscope observation results showed that the cell gap width decreased, and intercellular space per unit area increased (P<0.05).The treatment group was significantly better than the control group.Conclusion:In the treatment of NERD with spleen and stomach weakness for anti HP, Sijunzi decoction can significantly improve the curative effect, improve the HP negative rate, which is worthy of clinical application.