| 引用本文:高巍1，武忠2，李敏州2，张瑞霞2.糖肾通络汤对早期糖尿病肾病的临床观察[J].世界中医药,2018,(12):. |
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| 糖肾通络汤对早期糖尿病肾病的临床观察 |
| Clinical Observation on Tangshen Tongluo Decoction on Early Diabetic Nephropathy and Its Effects on Serum TGF-β1 and PEDF |
| 投稿时间：2016-07-18 |
| DOI：10.3969/j.issn.1673-7202.2018.12.012 |
| 中文关键词: 糖肾通络汤 糖尿病 肾病 早期 TGF-β1 PEDF 缬沙坦 |
| English Keywords:Tangshen Tongluo Decoction Diabetes mellitus Nephropathy Early stage TGF-β1 PEDF Valsartan |
| 基金项目:内蒙古科技计划项目(20130404) |
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| 中文摘要: |
| 目的:观察糖肾通络汤对早期糖尿病肾病的治疗效果。方法:选取2013年6月至2015年6月内蒙古自治区人民医院中医科收治的糖尿病肾病患者80例,按照随机数字表法分为观察组和对照组,每组40例,观察组采用糖肾通络汤治疗,对照组给予缬沙坦治疗,经3个月治疗后,观察疗效、中医症候积分、尿微量白蛋白(ALB)、血清肌酐(SCr)、空腹血糖(FBG)、糖化血红蛋白(HBA1C)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、转化生长因子(TGF-β1)和色素上皮衍生因子(PEDF)等。结果:观察组总有效率为92.5%(37/40),对照组75/100(30/40),2组比较差异有统计学意义(P<0.05);观察组治疗后中医证候积分较本组治疗前和对观察组后明显下降(P<0.05,P<0.01)。观察组ALB、SCr、FBG、HbA1C、TC、TG、LDL、TGF-β1和PEDF治疗后均显著低于治疗前;HDL治疗后显著高于治疗前。对照组治疗后,上述指标亦有改善(P<0.05,P<0.01)。观察组治疗后较对照组TG、HDL降低更明显(P<0.01,P<0.05)。结论:糖肾通络汤结合西医基础治疗早期糖尿病肾病有较好的疗效。 |
| English Summary: |
| To observe the therapeutic effects of Tangshen Tongluo Decoction on early diabetic nephropathy.Methods:A total of 80 patients with diabetic nephropathy admitted to the Department of Traditional Chinese Medicine,People's Hospital of Inner Mongolia Autonomous Region from June 2013 to June 2015 were selected and divided into observation group and control group according to the random number table method.There were 40 cases in each group.The observation group was treated with Tangshen Tongluo Decoction.The control group was treated with valsartan.After 3 months of treatment,the efficacy,TCM symptom scores,urinary microalbumin (ALB),serum creatinine (SCr),fasting blood glucose (FBG),glycosylated hemoglobin (HBA1C),total cholesterol (TC),triglycerides (TG),high-density lipoprotein (HDL),low-density lipoprotein (LDL),transforming growth factor (TGF-β1),pigment epithelium-derived factor (Pigment epithelium-derived factor,PEDF) were observed.Results:The total effective rate was 92.5% (37/40) in the observation group and 75/100 (30/40) in the control group.The difference between the two groups was statistically significant (P<0.05); The scores of syndromes were significantly lower than those before treatment and after treatment in the observation group (P<0.05,P<0.01).The ALB,SCr,FBG,HbA1C,TC,TG,LDL,TGF-β1 and PEDF in the observation group were (17.87±4.20) μg/mL,(88.75±5.60) μmol/L,(7.04±0.45) mmol/L,(7.19±0.20) mmol/L,(3.74±0.45) mmol/L,(1.39±0.32) mmol/L,(2.10±0.24) mmol/L,(17.54±3.14) ng/L,(10.96±2.19) μg/mL,all significantly lower than before treatment (25.56±3.24) μg/mL,(102.33±9.82) μmol/L,(7.36±0.28) mmol/L,(7.32±0.14) mmol/L,(4.32±0.64) mmol/L,(1.39±0.33) mmol/L,(2.43±0.40) mmol/L,(17.54±3.14) ng/L,(13.36±2.58) μg/mL,(P<0.05,P<0.01); after HDL treatment (1.72±0.28) mmol/L,significantly higher than before treatment (1.42±0.39) mmol/L (P<0.05,P<0.01).After treatment in the control group,the above indicators also improved (P<0.05,P<0.01).After treatment,TG and HDL (1.21±0.24) mmol/L and (1.66±0.34) mmol/L decreased more significantly in the observation group than in the control group (P<0.01,P<0.05).Conclusion:Tangshen Tongluo Decoction combined with basic western medicine has a good curative effect on early diabetic nephropathy. |
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