Abstract:To observe the therapeutic effects of Tangshen Tongluo Decoction on early diabetic nephropathy.Methods:A total of 80 patients with diabetic nephropathy admitted to the Department of Traditional Chinese Medicine,People's Hospital of Inner Mongolia Autonomous Region from June 2013 to June 2015 were selected and divided into observation group and control group according to the random number table method.There were 40 cases in each group.The observation group was treated with Tangshen Tongluo Decoction.The control group was treated with valsartan.After 3 months of treatment,the efficacy,TCM symptom scores,urinary microalbumin (ALB),serum creatinine (SCr),fasting blood glucose (FBG),glycosylated hemoglobin (HBA1C),total cholesterol (TC),triglycerides (TG),high-density lipoprotein (HDL),low-density lipoprotein (LDL),transforming growth factor (TGF-β1),pigment epithelium-derived factor (Pigment epithelium-derived factor,PEDF) were observed.Results:The total effective rate was 92.5% (37/40) in the observation group and 75/100 (30/40) in the control group.The difference between the two groups was statistically significant (P<0.05); The scores of syndromes were significantly lower than those before treatment and after treatment in the observation group (P<0.05,P<0.01).The ALB,SCr,FBG,HbA1C,TC,TG,LDL,TGF-β1 and PEDF in the observation group were (17.87±4.20) μg/mL,(88.75±5.60) μmol/L,(7.04±0.45) mmol/L,(7.19±0.20) mmol/L,(3.74±0.45) mmol/L,(1.39±0.32) mmol/L,(2.10±0.24) mmol/L,(17.54±3.14) ng/L,(10.96±2.19) μg/mL,all significantly lower than before treatment (25.56±3.24) μg/mL,(102.33±9.82) μmol/L,(7.36±0.28) mmol/L,(7.32±0.14) mmol/L,(4.32±0.64) mmol/L,(1.39±0.33) mmol/L,(2.43±0.40) mmol/L,(17.54±3.14) ng/L,(13.36±2.58) μg/mL,(P<0.05,P<0.01); after HDL treatment (1.72±0.28) mmol/L,significantly higher than before treatment (1.42±0.39) mmol/L (P<0.05,P<0.01).After treatment in the control group,the above indicators also improved (P<0.05,P<0.01).After treatment,TG and HDL (1.21±0.24) mmol/L and (1.66±0.34) mmol/L decreased more significantly in the observation group than in the control group (P<0.01,P<0.05).Conclusion:Tangshen Tongluo Decoction combined with basic western medicine has a good curative effect on early diabetic nephropathy.