To investigate the effects of replenishing qi and invigorating spleen and stomach therapy on chronicatrophic gastritis with spleen and stomach deficiency syndrome.Methods:A total of 100 chronicatrophic gastritis patients with spleen and stomach deficiency syndrome treated in the department of gastroenterology in Panzhihua Central Hospital from January 2016 to January 2018 were selected and divided into observation group and control group，each with 50 cases.The observation group received the invigorating spleen and stomach therapy，while the control group received the western medicine.The traditional Chinese medicine (TCM) syndrome scores，clinical efficacy，gastroscopy and glandular atrophy，chronic inflammation，intestinal gland metaplasia，and atypical dysplasia were compared before and after treatment in both groups.Results:After treatment，the TCM syndrome scores in the observation group were higher than those in the control group (P<0.05).The total clinical efficacy in the observation group was 90.0%，which was higher than 72.0% of the control group (P<0.05).The total efficiency of gastroscopy in the observation group was 88%，which was higher than 68% of the control group (P<0.05).The glandular atrophy，chronic inflammation，intestinal gland metaplasia，and atypical dysplasia showed no significant difference before treatment (P>0.05)，and there was statistic significance between the groups after the treatment (P<0.05).Conclusion:The clinical efficacy of replenishing qi and invigorating spleen and stomach therapy on chronicatrophic gastritis with spleen and stomach deficiency syndrome is significant，which can ameliorate the clinical symptoms，reduce the gastric gland atrophy degree，effectively control the inflammation extent，which is worthy of practice.