To investigate the effect of kirschner's needle internal fixation and mini-plate internal fixation combined with Chishen Zhuanggu decoction in the treatment of hand fracture.Methods:A total of 60 cases of patients with hand fracture,who was treated in Hospital of Tiefa Energy from January 2010 to January 2018,were selected,and were divided into observation group and control group by random digital table method.Each group had 30 cases.The control group was given kirschner's needle internal fixation,and the observation group was treated with mini-plate internal fixation.Both groups were treated with Chishen Zhuanggu decoction 3 days after operation,which was applied continuously for 2 months.The patients were regularly followed-up for 6 months after operation.A comparison was made between the 2 groups of hand function recovery,clinical indexes and bone metabolism after treatment.The conditions of fracture healing between 2 groups during following-up were recorded.Results:After treatment,the good rate of hand function of observation group and control group were 90.00% and 66.67% respectively,the good rate of hand function in observation group was significantly higher than that of control group (P<0.05).The operation time of observation group was longer than that of control group,the total active flexion degree of observation group was higher than that of control group,and the fracture healing time and hospitalization time were shorter than those of control group (P<0.01).The serum levels of BGP,OPG,BMP2 and IGF-I in 2 groups were significantly higher than those before treatment (P<0.01),but there was no significant difference between 2 groups after treatment (P>0.05).The incidence of delayed union and infection in observation group were significantly lower than those in control group during following-up (P<0.05).Conclusion:Compared with krschner wire internal fixation,mini-plate internal fixation is more effective in the treatment of hand fracture and has less interference to hand function.Combined with Chishen Zhuanggu decoction on the basis of fixation,it can significantly improve the fracture healing status of patients,which is worthy of clinical application.