To study the effects of Danhong injection combined with monosialic tetrahexose acid ganglioside on diabetic peripheral neuropathy (DPN) and its influence on nerve conduction velocity.Methods:A total of 120 DPN patients in the Department of Neurology of Haian Hospital affiliated to Nantong University from January 2016 to May 2018 were selected as the study subjects,and divided into the control group and the experiment group according to the hospital serial number parity,60 cases in each group.The 2 groups were treated with routine symptomatic treatment,the control group added the monosialic acid tetrahexose ganglioside on the basis of routine symptomatic treatment,the experimental group was treated with Danhong injection on the basis of the control group.The 4-week was 1 course,and the 2 groups were treated continuously for 2 courses.The clinical efficacy after treatment,blood glucose level and symptom score of peripheral neuropathy before and after treatment of TSS (Time-Sharing System) scores.Limb nerve conduction velocity changes of the 2 groups before and after treatment were compared.Results:The total effective rate of the experiment group was 90.00%,which was significantly higher than 75.00% of the control group (P<0.05).The FBG (Fasting Blood Glucose),2 hBG (2 Hours Postprandial Blood Glucose) levels and the TSS scores such as numbness,tingling,cramping and fatigue in the affected limbs significantly decreased in the 2 groups after treatment.The experimental group were significantly lower than those in the control group (P<0.05 or P<0.01).The SNCV (Sensory Nerve Conduction Velocity),MNCV (Motor Nerve Conduction Velocity) of median nerve,ulnar nerve and common peroneal nerve significantly increased in the 2 groups,and the experimental group was obviously higher than that of the control group (P<0.05 or P<0.01).Conclusion:Danhong injection combined with monosialic tetrahexose ganglioside can effectively relieve the clinical symptoms of patients with DPN and control their blood glucose level and improve nerve conduction velocity of affected limbs.The overall clinical efficacy is better than that of mouse nerve growth factor alone.