To study and analyze the effects of Xiaoji Zhike Oral Solution on the improvement of symptoms and humoral immunity in children with chronic cough.Methods:A total of 84 children with chronic cough admitted to Affiliated Traditional Chinese Medicine Hospital,Southwest Medical University from July 2016 to July 2018 were selected and divided into the observation group and the control group by random lottery,with 42 cases in each group.Both groups received conventional anti-infective therapy,and on this basis,the control group was treated with ambroxol hydrochloride syrup,and the observation group was treated with Xiaoji Zhike Oral Solution.The clinical efficacy,the time of clinical symptoms disappear,the humoral immune index level and the levels of inflammatory factors of the 2 groups before and after treatment were compared.Results:The total efficiency of the observation group was higher than the control group (P<0.05).The duration of cough,sputum,wheezing and lung rumbling in the observation group was shorter than those in the control group (all P<0.05).After treatment,IgG,IgA and IgM levels in the observation group were higher than the control group (all P<0.05).After treatment,the levels of serum IL-6 and TNF-α in the observation group were lower than those in the control group (all P<0.05).Conclusion:Xiaoji Zhike Oral Solution is effective in treating children with chronic cough,which can improve their clinical symptoms and signs,improve humoral immunity and reduce the degree of inflammatory response.