To investigate the clinical efficacy of cinobufotalin capsules combined with TP chemotherapy in the treatment of advanced cervical cancer.Methods:A total of 138 patients with advanced cervical cancer treated in the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture from January 2016 to January 2017 were selected and divided into the control group and the observation group according to the random number table method,with 69 cases in each group.The control group was treated with TP chemotherapy,and the observation group was treated with cinobufotalin capsules and TP chemotherapy,and the curative effects between the 2 groups were compared.Results:The total effective rate of the observation group was significantly higher than that of the control group (P<0.05),and there was no significant difference in platelet count,functional status score (KPS) and body mass between the 2 groups before treatment (P>0.05).After treatment,the platelet count of the observation group was significantly lower than that of the control group.The KPS score and body weight were significantly higher than the control group,and the difference was statistically significant (P<0.05).The incidence of gastrointestinal reactions and myelosuppression in the observation group was significantly lower than that in the control group (P<0.05).Conclusion:Cinobufotalin capsules combined with TP chemotherapy is effective and safe for advanced cervical cancer patients,which can be widely used.