To explore the clinical efficacy of Qingwei Jianzhong Decoction combined with esomeprazole in the treatment of peptic ulcer and its influnce on gastrointestinal hormones,inflammatory factor and hemorrheology.Methods:A total of 112 cases of patients with peptic ulcer in Heilongjiang Academy of Chinese Medicine from July 2015 to June 2016 were selected,and were randomly divided into treatment group (n=56) and control group (n=56).The control group was treated with esomeprazole,and the treatment group was added Qingwei Jianzhong Decoction on the basis of control group.Both groups were treated continuously for 1 month.The clinical efficacy in 2 groups was evaluated,and the changes of gastrointestinal hormones,inflammatory factor and hemorrheology in 2 groups were detected and compared.Results:The total effective rate of the treatment group was 98.21%,which was significantly higher than the 82.14% of the control group (P<0.05); Compared with data before treatment,the serum gastroenterin indexes of 2 groups were improved after treatment,and the improvement of treatment group was more obvious (P<0.05 or P<0.01); Compared with before treatment data,the levels of inflammatory factors,such as hs-CRP,IL-6 and TNF-α,the whole blood high,medium and low cutting viscosity,and the blood sedimentation and erythrocyte volume,were all decreased in different degrees (P<0.05 or P<0.01); The reduction of treatment group was more obvious than control group (P<0.05 or P<0.01).Conclusion:Qingwei Jianzhong Decoction combined with esomeprazole can effectively treat patients with peptic ulcer,reduce the level of inflammatory factors in patients,and strike a balance between the level of gastrointestinal hormones and hemorheology indicators,and its effect is remarkable.