| 引用本文:王晓蕴，赵红敏，张忠勇，李华君，金倩倩，郭煊，孔五宝，牛跃龙，李文东，韩中千.君子消痞汤治疗糖尿病胃轻瘫的临床疗效及其对胃肠道激素水平的影响[J].世界中医药,2018,(12):. |
|
| 君子消痞汤治疗糖尿病胃轻瘫的临床疗效及其对胃肠道激素水平的影响 |
| Clinical Efficacy of Junzi Xiaopi Decoction in the Treatment of Diabetic Gastroparesis and Effects on Gastrointestinal Hormone Level |
| 投稿时间：2018-06-29 |
| DOI：10.3969/j.issn.1673-7202.2018.12.026 |
| 中文关键词: 君子消痞汤 糖尿病胃轻瘫 临床疗效 植物神经功能 胃排空 血液流变学 胃肠道激素 症状评分 |
| English Keywords:Junzi Xiaopi Decoction Diabetic gastroparesis Clinical efficacy Autonomic nervous function Gastric emptying Hemorrheology Gastrointestinal hormones Symptom score |
| 基金项目:河北省中医药管理局科研计划项目(2016137)——君子消痞汤组方对糖尿病胃轻瘫临床疗效观察及机制探讨 |
|
| 摘要点击次数: 711 |
| 全文下载次数: 757 |
| 中文摘要: |
| 目的:观察君子消痞汤治疗糖尿病胃轻瘫的临床疗效及其对植物神经功能、胃排空情况、血液流变学及胃肠道激素水平的影响。方法:选取2016年1月至2017年12月沧州中西医结合医院收治的糖尿病胃轻瘫患者100例,按照随机数字表法随机分为对照组和观察组,每组50例。对照组给予甲钴胺粉针及莫沙必利口服,观察组在对照组治疗的基础上加用君子消痞汤治疗,观察2组患者的临床疗效,植物神经功能,胃排空情况,血液流变学及胃肠道激素水平变化情况。结果:对照组治疗后有12例患者出现植物神经功能异常,观察组有4例出现植物神经功能异常,2组比较差异有统计学意义(P<0.05)。治疗后,2组症状评分及胃排空时间明显降低,观察组上述指标下降更明显,差异有统计学意义(P<0.05)。与治疗前比较,2组治疗后血液流变学指标明显降低;观察组治疗后上述指标水平明显低于对照组治疗后水平(P<0.05)。与治疗前比较,2组治疗后GAS、MOT水平明显升高,CCK、SS水平明显降低;观察组治疗后GAS、MOT水平明显高于对照组治疗后水平(P<0.05),CCK、SS水平明显低于对照组治疗后水平(P<0.05)。观察组治疗后的总有效率(94.00%)明显高于对照组(78.00%),差异有统计学意义(P<0.05)。结论:君子消痞汤治疗糖尿病胃轻瘫可通过改善植物神经功能,调节胃肠道激素水平,改善血液流变学等机制,提高临床治疗效果。 |
| English Summary: |
| To observe the clinical efficacy of Junzi Xiaopi Decoction on diabetic gastroparesis and its effect on autonomic nervous function,gastric emptying,hemorrheology and gastrointestinal hormone levels.Methods:A total of 100 cases of diabetic gastroparesis treated in Cangzhou Hospital of Integrated Chinese and Western Medicine were selected and divided into control group and observation group according to random number table method,with 50 cases in each group.The control group was given Mecobalamin and Mosapride oral medicine.On the basis of the same treatment in the control group,the observation group was treated with the decoction of Junzi Xiaopi Decoction.The clinical effects,the changes of autonomic nervous function,gastric emptying,Hemorrheology and gastrointestinal hormone levels between the 2 groups were observed.Results:There were 12 cases of abnormal autonomic nervous function in the control group after treatment,and there were 4 cases of abnormal autonomic function patients in observation group,the difference was statistically significant (P<0.05).After treatment,the scores of symptoms and gastric emptying time in the 2 groups decreased significantly,and the above indexes in the observation group was decreased more significantly,and there was statistical significance (P<0.05).Compared with before the treatment,the level of gastrin (GAS),motillin (MOT) increased significantly,and the levels of cholecystokinin (CCK) and somatostatin (SS) decreased significantly.The levels of GAS and MOT in the observation group was significantly higher than that of the control group after treatment (P<0.05),and the levels of CCK and SS were significantly lower than those of the control group after treatment (P<0.05).The total effective rate in observation group (94.00%) was significantly higher than that of the control group (78.00%),there was statistical significance (P<0.05).Conclusion:Junzi Xiaopi Decoction can improve the autonomic nervous function,regulate the hormone level of gastrointestinal tract,improve the mechanism of blood rheology and improve the efficacy of clinical treatment. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
