To study the clinical efficacy of Nephritis Siwei Tablet on chronic glomerulonephritis (CGN) and its influence on immune function and inflammation indexes.Methods:A total of 116 CGN cases in Affiliated Renhe Hospital of China Three Gorges University from February 2015 to May 2017 were selected and randomly divided into observation group and control group with 58 cases in each group.The 2 groups were given conventional treatment such as controlling blood pressure,limiting diet and other conventional treatment.The control group was given Benazepril,and the observation group was given Nephritis Siwei Tablet.The 2 groups were continuously treated for 2 months.The clinical efficacy,the levels of serum inflammatory factors,the 24 h urinary protein quantification (24 h pro) and immune function of 2 groups were compared before and after treatment.Results:The total effective rate was 93.10% in the observation group,which was significantly higher than 79.31% in the control group (P<0.05).Compared with the data before treatment,the levels of Lkn-1,TNF-α,24 h pro in 2 groups and IL-6,IL-8 in observation group after treatment significantly decreased,and the observation group was significantly lower than those of the control group (P<0.05 or P<0.01).Compared with the data before treatment,the ratio of CD3+,CD4+and CD4+/CD8+in the observation group significantly increased,and the ratio of CD8+significantly decreased.The difference was statistically significant compared with the control group (P<0.01).Conclusion:Nephritis Siwei Tablet can reduce the levels of serum inflammatory factors and 24 h pro in CGN patients,control the progress of inflammation,improve the immune function of the body,and enhance the clinical efficacy.