To observe the clinical effect of Guizhi Fuling Pill on macular edema after diabetic cataract surgery，and to evaluate its effect on interferon IP-10 (Inducible protein-10)，MCP-1 (macrophage chemoattractant protein-1) and VEGF (vascular endothelial growth factor).Methods:A total of 60 patients with macular edema after diabetic cataract surgery treated in Chengdu First People's Hospital from January 2016 to January 2017 were selected and randomly divided into the control group and the observation group with 30 cases in each group.The control group using the Pla Lo Finn eye drops，tobramycin and dexamethasone eye drops treatment，and the observation group added the use of Guizhi Fuling Pill based on the treatment of the control group.Both groups received treatment for 4 weeks.After treatment，clinical curative effect，TCM Syndrome integral，retinal thickness of macular fovea，IP-10，MCP-1 and VEGF concentration of the patients in the two groups were compared，while the retinal thickness of macular fovea and IP-10，MCP-1 and VEGF concentration correlation were analyzed.Results:1) After treatment，the total efficiency of the observation group 89%，and the difference was statistically significant compared with 68% in the control group (P<0.05); 2) After treatment，the TCM syndrome integral of the two groups were decreased，and the observation group was superior than the control group (P<0.05); 3) After the treatment，the retinal thickness of macular fovea of two groups decreased significantly，which suggested significant difference compared with before treatment (P<0.05).The retinal thickness of macular fovea decreased significantly in the observation group compared with the control group，and the difference was statistically significant (P<0.05); 4) After the end of treatment，observation group fundus conditions were better than the control group，and the difference was statistically significant (P<0.05); 5) After treatment，the IP-10，MCP-1 and VEGF concentrations of two groups of patient had different degrees of reduction，the improvement trend was more obvious in the observation group，and the difference was statistically significant (P<0.05); 6) There was a positive correlation between the retinal thickness of macular fovea and the concentration of IP-10，MCP-1 and VEGF (P<0.05).Conclusion:Guizhi Fuling Pill can significantly improve the condition of macular edema after diabetic cataract surgery，and its mechanism may be related to the inhibition of neovascularization and the improvement of choroidal circulation.