To explore the efficacy and safety of Gegen Qinlian Decoction combined with orthodontic treatment for severe periodontitis patients.Methods:A total of 107 cases of patients with severe periodontitis patients that admitted in our hospital stomatology department from March 2017 to May 2018 were selected and divided into control group (n=53) and observation group (n=54) according to random number table method.All patients were treated with basic periodontal therapy,control group was treated with orthodontic treatment on the basis of basic periodontal therapy,observation group was treated with Gegen Qinlian Decoction on the basis of control group,2 groups were treated for 3 months continuously.The clinical efficacy in 2 groups were detected after treatment,the improvement circumstance of major Traditional Chinese Medicine (TCM) syndromes,periodontal indicators and the changes of inflammatory factors levels in gingival crevicular fluid in 2 groups before and after treatment were detected and compared; the occurrence of related untoward reaction during the treatment in 2 groups were recorded and compared.Results:The total clinical effective rate of observation group increased to 96.30%,which was higher than 75.47% of control group (P<0.01); compared with before treatment data,the major Traditional Chinese Medicine (TCM) points of bad breath,swollen gums,bleeding gums,loose teeth,periodontal overflow pus,urine yellow and SBI,GI,PLI decreased in 2 groups after treatment,and observation group was lower than control group (P<0.01); the PD shortened in 2 groups,and observation group was shorter than control group (P<0.01); compared with before treatment data,the IL-6,IL-1β,TNF-α,PGE2 levels in gingival crevicular fluid of observation group decreased after treatment,which were lower than those of control group (P<0.01); there was no severe adverse reactions of patients in 2 groups during the treatment.Conclusion:Gegen Qinlian Decoction combined with orthodontic treatment can improve the clinical symptoms,periodontal indicators of severe periodontitis patients effectively,and reduce the body's inflammatory factors levels remarkably,inhibit the periodontal inflammatory response,the clinical efficacy is better than orthodontic treatment alone,and which has higher security.