To explore the curative effects of Compound Radix Lithospermi Oil on diaper dermatitis.Methods:A total 100 cases of diaper dermatitis in Children's Hospital of Kaifeng City from August 2015 to February 2017 were selected.The patients were divided into observation group (50 cases) and control group (50 cases) by random number table.Before and after treatment,disinfection cotton swabs were used to sample the skin lesions of the children with moderate and severe diaper dermatitis,and bacterial culture was conducted to observe the bacterial test results.Children in the control group were routinely given zinc oxide oil,while those in the observation group were treated with Compound Radix Lithospermi Oil.The overall efficacy of the two groups was compared,and the skin loss area score,erythema and erosion resolution time and adverse reactions of the children with wound infection were compared between the two groups.Results:The curative effect of the observation group was better than that of the control group,and the difference was statistically significant (P<0.05).After treatment,there were one case in observation group and seven cases in control group were positive,the bacteria inspection results in the observation group was significantly better than that in control group.The difference was statistically significant (P<0.05).After treatment,the skin lesion area score of the observation group was lower than that of the control group,and the erythema and erosion resolution time of the observation group was lower than that of the control group,both the differences were statistically significant (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion:Compound Radix Lithospermi Oil is effective in treating infantile diaper dermatitis with high safety and less side effects,which is worthy of clinical promotion and application.