To investigate the dynamic changes of macroscopic characteristics in the development and evolution from ischemic stroke to post-stroke depression,anxiety and vascular dementia and the intervention effect of Yinao Jieyu Decoction.Methods:Male Wistar rats were randomly divided into ischemic stroke (IS) model group,IS therapy group,IS sham-operation group,post-stroke depression (PSD) model group,PSD therapy group,PSD sham-operation group,post-stroke anxiety (PSA) model group,PSA therapy group,PSA sham-operation group,vascular dementia (VaD) model group,VaD therapy group and normal group.Middle cerebral artery occlusion (MCAO) was operated in rats except those in normal group and sham-operation groups.After the operation for 7 days,PSD groups were given chronic unpredictable mild stress (CUMS) and isolation rearing for 21 days for duplicating PSD model,the PSA groups were accompanied by empty water bottle stimulation for 21 days for duplicating PSA model.After the operation for 28 days,the VaD groups were selected by Morris water maze,then put into the test.The IS groups were gavaged for 2 weeks after the operation,the other groups were gavaged for 4 weeks after modeling.Therapy groups were given Yinao Jieyu Decoction while model groups and sham-operation groups were given distilled water.Rats macroscopic characteristics were dynamically collected and the weight changes of rats in IS groups at the first and second weeks,PSD,PSA,and VaD groups at the first,second and forth weeks were compared.Results:In the evolution form stroke to PSD,rats showed irritability first,then the activity,mental state and reactivity gradually decreased.PSD rats represented dim lips and nose,dark purple tongue and purple sublingual vein.In the evolution from stroke to PSA,aggressive and explorative behaviors were increased,grooming behaviors were decreased.PSA rats represented dim lips and nose,red tongue with scant liquid.In the evolution from stroke to VaD,rats showed progressive decline in activity,mental status and responsiveness.VaD rats represented light lip color,moistened tongue and pink tongue.The weight of rats in model groups was significantly lower than that in the normal group.After the intervention of Yinao Jieyu Decoction,the macroscopic characteristics of rats were improved in therapy groups,and the body weight was increased significantly.Conclusion:PSD,PSA and VaD have a common pathogenesis of kidney deficiency and liver turbidity in the course of their evolution,Yinao Jieyu Decoction with the actions of replenishing kidney and regulating qi has a certain effect on ischemic stroke and mental disorders after stroke.