To establish rats model of tourette's syndrome (TS) in mouse with liver stagnation and spleen deficiency syndrome,and to explore the general characteristics of the model.Methods:After the induction of iminodipropionitrile (IDPN) by intraperitoneal injection,a rat model of multiple tic disorder with liver stagnation and spleen deficiency was established by eating dislocation,chronic restraint and excessive fatigue.The independent activity counts,stereotyped movement score,body weight,food intake,feces granu,thymus and spleen index,gastrin,D-xylose and other indexes were used to evaluate TS mouse of spleen deficiency.Results:In the model group and the liver stagnation and spleen deficiency group,the activity distance and the average speed of the rats in the same time were significantly increased compared with the blank control group.The food intake of rats in the liver stagnation and spleen deficiency group decreased,and the thymus index,spleen index,gastrin and D-xylose concentrations were statistically different (P<0.05).Conclusion:This model has relatively stable tic symptoms,and has some similar symptoms of liver stagnation and spleen deficiency syndrome,and to some extent has the surface validity of multiple tic disorder liver stagnation and spleen deficiency syndrome.