To evaluate the therapeutic effects of Shenfukang on fibrosis model rats and to observe its effect on the expression of TGF-β1，Smad2 and Smad7 in renal tissues.Methods:A total of 70 SD rats were randomly divided into sham operation group，Shenfukang group and model group.The rats in both Shenfukang group and model group were treated with renal interstitial fibrosis model.Rats receiving different doses of Shenfukang gavage on the 2nd day after building the model.Model group and sham operation group received equal volume of saline gavage，and both group were given intervention for 21 days.At the end of the intervention，the urine of each group was collected for 24 h，and the urinary protein in 24 h (24 UP)，serum creatinine (SCr)，blood urea nitrogen (BUN) levels were detected.The samples were collected after being decapitated.HE staining was used to evaluate the pathological changes of renal tissue in each group，immunohistochemical method was used to detect the changes of TGF-beta 1 protein in renal tissue in rats，Western blotting method was used to detected Smad2，Smad7 concentration.Results:1）Compared with the sham operation group，the levels of 24 UP，SCr and BUN in the Shenfukang group and model groups significantly increased (P<0.05).Compared with the model group，the level of 24 UP，SCr and BUN decreased (P<0.05)，and with the increasing dose of Shenfukang the trend was more obvious.2）Compared with the sham operation group，the renal tissue pathological score of Shenfukang group and model group were significantly increased，among which the pathological score of Shenfukang group was lower than the model group (P<0.05)，and the pathological score decreased gradually with the increase of the dosage of Shenfukang.3）There was little expression of TGF-β1 and Smad2 in renal tissue of the sham operation group and high expression of TGF-β1 and Smad2 in the model group.The concentration of TGF-β1 and Smad2 decreased gradually with the increase of Shenfukang concentration.After modeling，the concentration of Smad7 decreased，and the concentration of Smad7 was increased after Shenfukang intervention，and the trend was more obvious with the increase of concentration.Conclusion:Shenfukang can obviously improve the condition of rats with renal interstitial fibrosis.Its mechanism may be related to the mediate of TGF-β1，Smad2，and Smad7 in kidney tissues in a dose-dependent manner