To investigate the effects of lipid-lowering mixture on blood lipid metabolism,LDL oxidative susceptibility and blood viscosity and coagulation in experimental hyperlipidemia rats.Methods:A total of 60 male Wistar rats were selected and randomly divided into 6 groups,with 10 rats in each group,which were divided as low,middle and high lipid-lowering mixture dose group and simvastatin group,model group and control group.The control group was fed with basal diet,other groups of rats were fed with high fat diet to establish hyperlipidemia rats model.Prophylactic administration was simultaneously performed during the modeling process,and lipid metabolism,LDL oxidative susceptibility,and blood coagulation state were measured 10 weeks after the rats in each group.Results:The antioxidant capacity of serum LDL-C in the model group rats was decreased significantly,and LDL serum antioxidant capacity in simvastatin group and three groups of lipid-lowering mixture group was significantly enhanced,and the antioxidant capacity of LDL in the high and middle lipid-lowering mixture dose groups was significantly superior to that in the middle dose group (P<0.05).The effects of high and middle lipid-lowering mixture groups on EET and ETA p,ETA B (high,medium and low shear),IED,HCT,the role of the IEA were superior to those of low lipid-lowering mixture group (P<0.05 or P<0.05).Conclusion:Lipid-lowering mixture can effectively regulate the blood lipid metabolism and blood viscosity concentration coagulation state in experimental hyperlipidemia rat,which also has a good regulation effect on lipid-lowering mixture in blood lipid and blood flow abnormality and curative effect.