| 引用本文:王杰，黄韵，劳国平，梁健忠.扶正解毒方联合艾灸对鼻咽癌患者放化疗后口腔黏膜损伤及炎性反应的影响[J].世界中医药,2018,(12):. |
|
| 扶正解毒方联合艾灸对鼻咽癌患者放化疗后口腔黏膜损伤及炎性反应的影响 |
| Effects of Fuzheng Jiedu Decoction Combined with Moxibustion on Oral Mucosal Injury and Inflammation in Patients with Nasopharyngeal Carcinoma after Radiotherapy and Chemotherapy |
| 投稿时间：2018-10-29 |
| DOI：10.3969/j.issn.1673-7202.2018.12.042 |
| 中文关键词: 扶正解毒方加减 艾灸 鼻咽癌 放化疗 口腔黏膜损伤 炎性反应 |
| English Keywords:Fuzheng Jiedu decoction Moxibustion Nasopharyngeal carcinoma Radiotherapy and chemotherapy Oral mucosa injury Inflammation |
| 基金项目:广西壮族自治区卫生和计划生育委员会中医药科技专项(GZLC16-67) |
|
| 摘要点击次数: 770 |
| 全文下载次数: 737 |
| 中文摘要: |
| 目的:探讨扶正解毒方加减联合艾灸对鼻咽癌患者放化疗后口腔黏膜损伤及炎性反应的影响。方法:选取2016年1月至2017年10月梧州市红十字会医院收治的鼻咽癌患者105例为研究对象,所有患者均行放化疗治疗,之后按照治疗方法的不同分为中药+艾灸组、中药组与对照组,每组35例。观察3组患者临床疗效;比较3组患者放化疗后口腔黏膜损伤状况;检测并比较3组血清中炎性反应因子水平。结果:治疗后中药+艾灸组、中药组、对照组的总有效率分别为77.14%、61.76%、58.82%,3组间总有效率差异有统计学意义(P<0.01),且中药+艾灸组总有效率高于中药组与对照组。治疗后中药+艾灸组放射性口腔黏膜炎分级为Ⅰ级、Ⅱ级的患者例数较治疗前显著增加,Ⅲ级、Ⅳ级患者例数显著减少,且Ⅰ级患者例数/Ⅲ级、Ⅳ级患者例数分别显著少于/多于中药组与对照组(P<0.05或P<0.01);治疗后中药+艾灸组、中药组患者口腔内PH值及3组VAS评分较治疗前显著下降,且中药+艾灸组显著低于中药组与对照组(P<0.05或P<0.01)。治疗后3组血清中TGF-β1、IL-6、CRP水平均较治疗前显著下降,且中药+艾灸组显著低于中药组与对照组(P<0.01)。治疗后3组间消化道反应、骨髓抑制及唾液腺损伤等不良反应发生率差异均无统计学意义(P>0.05)。结论:扶正解毒方加减联合艾灸可有效减轻鼻咽癌患者放化疗后口腔黏膜损伤,并控制炎性反应进展,提升整体疗效。 |
| English Summary: |
| To study the effects of Fuzheng Jiedu Decoction combined with moxibustion on oral mucosal injury and inflammation in patients with nasopharyngeal carcinoma after radiotherapy and chemotherapy.Methods:A total of 103 patients with nasopharyngeal carcinoma admitted to Wuzhou Red Cross Hospital from January 2016 to October 2017 were selected as the research objects.All patients were treated with radiotherapy and chemotherapy.Then they were divided into Chinese herbal medicine+moxibustion group,Chinese herbal medicine group and control group according to the different treatment methods,(35 vs 34 vs 34).The clinical efficacy of 3 groups of patients was observed.The oral mucosal lesions after radiotherapy and chemotherapy were compared among 3 groups,and the levels of serum inflammatory factors were detected and compared among 3 groups.Results:After treatment,the total effective rates of Chinese herbal medicine+moxibustion group,Chinese herbal medicine group and control group were 77.89%,65.66% and 59.00% respectively.There were significant differences among 3 groups,and the total effective rate of Chinese herbal medicine+moxibustion group was higher than that of Chinese herbal medicine group and control group (P<0.01).After treatment,the number of patients with radiation oral mucositis grade I and II of Chinese herbal medicine+moxibustion group increased significantly,and the number of patients with radiation oral mucositis grade III and IV decreased significantly.The ratio of patients with radiation oral mucositis grade I to grade III was significantly less than in Chinese herbal medicine group and control group.The ratio of patients with radiation oral mucositis grade I to grade IV was more than in Chinese herbal group and control group (P<0.05 or P<0.01).After treatment,PH value in oral cavity and the VAS scores of 3 groups were significantly lower than those before treatment.Chinese herbal medicine+moxibustion group was significantly lower than that of Chinese herbal group and control group (P<0.05 or P<0.01).After treatment,the serum levels of TGF-β1,IL-6,CRP in 3 groups decreased significantly than those before treatment.The Chinese medicine+moxibustion group were significantly lower than those in Chinese herbal group and control group (P<0.01).After treatment,there was no significant difference in the incidence of adverse reactions such as gastrointestinal reaction,bone marrow suppression and salivary gland injury (P>0.05).Conclusion:Fuzheng Jiedu Decoction combined with moxibustion can effectively alleviate oral mucosal injury in patients with nasopharyngeal carcinoma after radiotherapy and chemotherapy,control the progress of inflammation,alleviate other adverse reactions,and enhance the overall efficacy. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
