To study the effects of Fuzheng Jiedu Decoction combined with moxibustion on oral mucosal injury and inflammation in patients with nasopharyngeal carcinoma after radiotherapy and chemotherapy.Methods:A total of 103 patients with nasopharyngeal carcinoma admitted to Wuzhou Red Cross Hospital from January 2016 to October 2017 were selected as the research objects.All patients were treated with radiotherapy and chemotherapy.Then they were divided into Chinese herbal medicine+moxibustion group,Chinese herbal medicine group and control group according to the different treatment methods,(35 vs 34 vs 34).The clinical efficacy of 3 groups of patients was observed.The oral mucosal lesions after radiotherapy and chemotherapy were compared among 3 groups,and the levels of serum inflammatory factors were detected and compared among 3 groups.Results:After treatment,the total effective rates of Chinese herbal medicine+moxibustion group,Chinese herbal medicine group and control group were 77.89%,65.66% and 59.00% respectively.There were significant differences among 3 groups,and the total effective rate of Chinese herbal medicine+moxibustion group was higher than that of Chinese herbal medicine group and control group (P<0.01).After treatment,the number of patients with radiation oral mucositis grade I and II of Chinese herbal medicine+moxibustion group increased significantly,and the number of patients with radiation oral mucositis grade III and IV decreased significantly.The ratio of patients with radiation oral mucositis grade I to grade III was significantly less than in Chinese herbal medicine group and control group.The ratio of patients with radiation oral mucositis grade I to grade IV was more than in Chinese herbal group and control group (P<0.05 or P<0.01).After treatment,PH value in oral cavity and the VAS scores of 3 groups were significantly lower than those before treatment.Chinese herbal medicine+moxibustion group was significantly lower than that of Chinese herbal group and control group (P<0.05 or P<0.01).After treatment,the serum levels of TGF-β1,IL-6,CRP in 3 groups decreased significantly than those before treatment.The Chinese medicine+moxibustion group were significantly lower than those in Chinese herbal group and control group (P<0.01).After treatment,there was no significant difference in the incidence of adverse reactions such as gastrointestinal reaction,bone marrow suppression and salivary gland injury (P>0.05).Conclusion:Fuzheng Jiedu Decoction combined with moxibustion can effectively alleviate oral mucosal injury in patients with nasopharyngeal carcinoma after radiotherapy and chemotherapy,control the progress of inflammation,alleviate other adverse reactions,and enhance the overall efficacy.