Abstract:To investigate efficacy of Shaofu Zhuyu Decoction and moxibustion combined with dydrogesterone in treating adolescent dysmenorrhea with syndrome of congealing cold with blood stasis,and the influences on serum levels of sex hormone.Methods:A total of 110 adolescent dysmenorrhea patients in our hospital from June 2015 to June 2017 were divided into control group(n=55)and treatment group(n=55)using randomized clinical trials method.The control group was orally administrated with ibuprofen capsules(1 particle/time).The treatment group was administrated with Shaofu Zhuyu Decoction and moxibustion combination with dydrogesterone.All cases were observed for 3 menstrual cycles.The change of visual analogue scale(VAS),scores of dysmenorrhea symptoms,duration time were compared,and serum CA125,follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),prolactin(PRL),and progesterone(P)protein levels were detected and evaluated.Results:The VAS and scores of dysmenorrhea symptoms and duration time of treatment group were remarkably lower than that of control group after treatment(2.12±0.25 vs.4.03±0.49; 3.12±0.34 vs.6.21±0.72; 3.01±0.11 vs.4.31±0.49; all P<0.01).The total effective rate of the treatment group was significantly higher than the control group(94.55% vs.78.18%,P<0.05).Meanwhile,the treatment group could significantly decrease the serum CA125 level(20.05±2.17 vs.31.44±3.67,P<0.01),and down-regulated the expression levels of FSH,LH,E2 and PRL(7.52±0.86 vs.11.45±1.31; 8.24±0.98 vs.11.68±1.33; 21.01±3.08 vs.26.41±3.34; 20.06±2.85 vs.25.06±4.89,all P<0.01).Conclusion:Shaofu Zhuyu Decoction and moxibustion combined with dydrogesterone could inhibit the levels of serum FSH,LH,E2 and PRL,and improve the syndrome of adolescent dysmenorrhea patients.