| 引用本文:阮宝华，周秀春，李莉.少腹逐瘀汤加艾灸联合地屈孕酮治疗青春期痛经的临床效果[J].世界中医药,2018,(12):. |
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| 少腹逐瘀汤加艾灸联合地屈孕酮治疗青春期痛经的临床效果 |
| Clinical Research on Shaofu Zhuyu Decoction and Moxibustion Combination with Dydrogesterone in Treating Adolescent Dysmenorrhea |
| 投稿时间：2018-01-23 |
| DOI：10.3969/j.issn.1673-7202.2018.12.046 |
| 中文关键词: 少腹逐瘀汤 艾灸 地屈孕酮 青春期痛经 卵泡生成激素 黄体生成激素 雌二醇 催乳激素 |
| English Keywords:Shaofu Zhuyu Decoction Moxibustion Dydrogesterone Adolescent dysmenorrhea FSH LH E2 PRL |
| 基金项目:江门市卫生科技计划项目［江科（2016）104号］ |
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| 中文摘要: |
| 目的：探讨少腹逐瘀汤加艾灸联合地屈孕酮治疗青春期痛经寒凝血瘀证的疗效及对血清性激素水平的影响。方法：选取2015年6月至2017年6月江门市新会保健院收治的的青春期痛经患者110例，采用前瞻性随机临床对照研究方法，按数字表法随机分为观察组和对照组，每组55例。对照组口服布洛芬，1粒/次，2次/d；观察组采取少腹逐瘀汤加艾灸联合地屈孕酮治疗。2组均观察3个月经周期。对2组患者疼痛视觉模拟评分法（VAS）、痛经症状评分、痛经持续时间评分，以及血清CA125、卵泡生成激素（FSH）、黄体生成激素（LH）、雌二醇（E2）、催乳激素（PRL）及孕酮（P）蛋白水平进行评价。结果：经过3个月经周期治疗，与对照组比较，观察组能明显降低患者VAS评分（2.12±0.25）分比(4.03±0.49）分，差异有统计学意义（P<0.05)；改善痛经症状评分（3.12±0.34）分比(6.21±0.72)分，差异有统计学意义（P<0.05)；减少痛经持续时间（3.01±0.11）d比(4.31±0.49）d，差异有统计学意义（P<0.05)；观察组总有效率明显高于对照组（94.55％比78.18％，P<0.05）；同时，观察组能够明显降低患者血清CA125水平（20.05±2.17）IU/mL比(31.44±3.67)IU/mL，差异有统计学意义（P<0.05)，下调患者FSH、LH、E2、PRL表达（7.52±0.86)IU/L比（11.45±1.31）IU/L;(8.24±0.98）IU/L比（11.68±1.33）IU/L;(21.01±3.08）nmol/L比（26.41±3.34）nmol/L;(20.06±2.85）IU/L比（25.06±4.89）IU/L，差异有统计学意义（P<0.05)。结论：少腹逐瘀汤加艾灸联合地屈孕酮可能通过抑制血清FSH、LH、E2、PRL蛋白表达水平进而起到改善青春期痛经患者临床症状及体征。 |
| English Summary: |
| To investigate efficacy of Shaofu Zhuyu Decoction and moxibustion combined with dydrogesterone in treating adolescent dysmenorrhea with syndrome of congealing cold with blood stasis,and the influences on serum levels of sex hormone.Methods:A total of 110 adolescent dysmenorrhea patients in our hospital from June 2015 to June 2017 were divided into control group(n=55)and treatment group(n=55)using randomized clinical trials method.The control group was orally administrated with ibuprofen capsules(1 particle/time).The treatment group was administrated with Shaofu Zhuyu Decoction and moxibustion combination with dydrogesterone.All cases were observed for 3 menstrual cycles.The change of visual analogue scale(VAS),scores of dysmenorrhea symptoms,duration time were compared,and serum CA125,follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),prolactin(PRL),and progesterone(P)protein levels were detected and evaluated.Results:The VAS and scores of dysmenorrhea symptoms and duration time of treatment group were remarkably lower than that of control group after treatment(2.12±0.25 vs.4.03±0.49; 3.12±0.34 vs.6.21±0.72; 3.01±0.11 vs.4.31±0.49; all P<0.01).The total effective rate of the treatment group was significantly higher than the control group(94.55％ vs.78.18％,P<0.05).Meanwhile,the treatment group could significantly decrease the serum CA125 level(20.05±2.17 vs.31.44±3.67,P<0.01),and down-regulated the expression levels of FSH,LH,E2 and PRL(7.52±0.86 vs.11.45±1.31; 8.24±0.98 vs.11.68±1.33; 21.01±3.08 vs.26.41±3.34; 20.06±2.85 vs.25.06±4.89,all P<0.01).Conclusion:Shaofu Zhuyu Decoction and moxibustion combined with dydrogesterone could inhibit the levels of serum FSH,LH,E2 and PRL,and improve the syndrome of adolescent dysmenorrhea patients. |
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