To investigate the preventive effect of percutaneous acupoint electrical stimulation (TAES) combined with azasetron on postoperative nausea and vomiting (PONV) in patients with craniotomy.Methods:A total of 80 patients who underwent craniotomy in Dalian Central Hospital from January 2016 to January 2017 were selected and divided into observation group (n=40) and control group (n=40) according to random number table method.All patients underwent craniotomy,azasetron was given when the dura was sutured.The patients in the observation group were treated with transcutaneous acupoint electrical stimulation (TAES) after waking up,the control group was placed on the corresponding acupuncture points,but no current acupoint stimulation.The clinical efficacy,the degree of severity of nausea and vomiting at different time points and the levels of plasma motilin (MTL) before and after surgery were compared between the 2 groups,the postoperative adverse reactions of the 2 groups were recorded.Results:After surgery,the total efficiency of the observation group was 90.00%,which was significantly higher than 72.50% of the control group (P<0.05).The scores of nausea and vomiting significantly decreased from 2 to 24 hours after surgery in the 2 groups,and the observation group was significantly lower than the control group at the same time (P<0.05 or P<0.01).Compared with pre-anesthesia,the levels of plasma MTL significantly increased in 12 hours after surgery in the observation group and 12 and 24 hours postoperation in the control group,and the levels of plasma MTL 12 and 24 hours postoperation in the observation group was significantly lower than that of the control group (P<0.01); the levels of plasma MTL recovered to the pre-anesthesia state 24 hours postoperation in the observation group and 48 hours postoperation in the control group (P>0.05).The incidence of total adverse reactions in the experiment group was significantly lower than that in the control group (P<0.05).Conclusion:TAES combined with azasetron has little effect on the levels of plasma MTL in patients undergoing craniotomy,it can effectively reduce the incidence of PONV,improve the degree of severity of nausea and vomiting,and the clinical efficacy is better than azasetron alone.