To evaluate analgesic effects and mechanism research of Feiyang(BL 58)acupoint on lumber disc herniation.Methods:One hundred cases of lumbar disc herniation treated in our hospital from January 2012 to December 2016,were included and randomly divided into control group and observation group by random number table method,with 50 cases in each group.Both groups were given routine acupuncture combined spinal massage,and additionally observation group was given needling of Feiyang(BL 58)acupoint,1 time,30 min/time,continuous treatment of 10 d.The changes of simple McGill pain score,JOA score,lumbar flexion mobility,quality of life,surface electric in lumber muscle and prostaglandin E2(PGE2),β-endorphin(β-EP)concentration were compared before and after treatment in 2 groups.Results:1)Simple McGill pain score and JOA scores were improved in both groups.The observation group was better than control group obviously and the difference was statistically significant(P<0.05).2)Front pike position of lumbar flexion mobility and quality of life was improved in both groups.The observation group was better than control group(P<0.05).3)AEMG,MF,and MPF of erector muscle of spine and multifidus of observation group were better than control group(P<0.05).4)PGE2 of peripheral blood levels had fallen in both groups after treatment.β-EP concentration increased.The observation group was better than control group in the improvement trend.It had statistically significant difference(P<0.05).Conclusion:Acupuncture on Feiyang(BL 58)acupoint can significantly improve the pain threshold of lumbar disc herniation,which may be related with reducing peripheral blood PGE2,and improving the concentration ofβ-EP.