To predict and explore the mechanism of Mongolian medicine in the treatment of Sa disease by means of computer-aided data mining and pharmacological methods.Methods:Based on the literature and clinical collection of Sa disease prescriptions，combined with data mining methods，complex network analysis methods and expert discussion，the core of Sa disease was determined.With the help of network pharmacological analysis platform，the information and channel information of the Sa disease related targets corresponding to the core prescriptions were obtained.The above information was further analyzed and the effecting mechanism of Mongolian medicine intervention on Sa disease was predicted.Results:The core prescription of Mongolian medicine was composed of 5 kinds of drugs such as musk.33 targets related to SAD were obtained,involving 58 compounds.Conclusion:The therapeutic effect of the core prescription of Mongolian medicine on SAD from the neurovascular unit level may be regulated by 17β-estradiol,sitosterol,cinnamaldehyde,eugenol,and so on,through the regulation of neuroactive ligand-receptor interaction pathway,calcium signal pathway,and so on.Dopaminergic synapses and other pathways in the ESR1/2,F2,AKT1,GRIN2B,DRD2/3,HTR1A/2A and other related proteins to achieve.