| 引用本文:满达，木其尔，白明慧，马十月，黄树青，金萨出茹拉，特木其乐.计算机辅助蒙药治疗萨病的作用机制[J].世界中医药,2018,(12):. |
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| 计算机辅助蒙药治疗萨病的作用机制 |
| Exploration on the Mechanism of Mongolian Medicine in the Treatment of Sa Disease with Computer |
| 投稿时间：2018-03-16 |
| DOI：10.3969/j.issn.1673-7202.2018.12.051 |
| 中文关键词: 蒙药 数据挖掘 网络药理学 萨病 药物频次 关联规则挖掘 复杂网 核心配伍 |
| English Keywords:Mongolian medicine Data mining System pharmacology Sa disease Drug frequency analysis Mining association rules Complex network analysis Determination of core compatibility |
| 基金项目:2017年度内蒙古自治区卫生计生科研项目计划(201703021);内蒙古自治区科技创新引导项目(2017年课题，无编号);内蒙古自治区自然科学基金项目（2015MS08134）；中国民族医药学会科研项目（2017KYXM-M117-74） |
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| 中文摘要: |
| 目的：通过计算机辅助的数据挖掘以及药理学方法，预测、探讨蒙药治疗萨病的作用机制。方法：选取文献及临床收集萨病方剂，结合数据挖掘方法、复杂网络分析方法及专家讨论意见，确定萨病核心方。借助网络药理分析平台得到核心方剂对应的萨病相关靶点信息及通路信息。对上述信息进行进一步分析，得到蒙药干预萨病的作用机制预测结果。结果：蒙药核心方由麝香等5味药物组成，共得到与萨病有关靶点33个，涉及58个化合物。结论：蒙药核心方从神经血管单元层面治疗萨病的作用，可能是通过17β雌二醇、谷甾醇、肉桂醛、丁香酚等成分，调节神经活性配体-受体互作用通路、钙离子信号通路、多巴胺能神经突触等通路上的ESR1/2、F2、AKT1、GRIN2B、DRD2/3、HTR1A/2A等相关蛋白来实现的。 |
| English Summary: |
| To predict and explore the mechanism of Mongolian medicine in the treatment of Sa disease by means of computer-aided data mining and pharmacological methods.Methods:Based on the literature and clinical collection of Sa disease prescriptions，combined with data mining methods，complex network analysis methods and expert discussion，the core of Sa disease was determined.With the help of network pharmacological analysis platform，the information and channel information of the Sa disease related targets corresponding to the core prescriptions were obtained.The above information was further analyzed and the effecting mechanism of Mongolian medicine intervention on Sa disease was predicted.Results:The core prescription of Mongolian medicine was composed of 5 kinds of drugs such as musk.33 targets related to SAD were obtained,involving 58 compounds.Conclusion:The therapeutic effect of the core prescription of Mongolian medicine on SAD from the neurovascular unit level may be regulated by 17β-estradiol,sitosterol,cinnamaldehyde,eugenol,and so on,through the regulation of neuroactive ligand-receptor interaction pathway,calcium signal pathway,and so on.Dopaminergic synapses and other pathways in the ESR1/2,F2,AKT1,GRIN2B,DRD2/3,HTR1A/2A and other related proteins to achieve. |
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