To explore the molecular mechanism of Sanhuang Decoction in treating type 2 diabetes mellitus (T2DM) based on network pharmacology and molecular docking.Methods:The effective chemical constituents of Sanhuang Decoction were screened based on the network pharmacology platform，and the target gene of type 2 diabetes was screened by CTD.The molecular function of potential targets were analyzed by DAVID 6.8.At the same time，STRING was used for gene interaction analysis to screen key target genes of type 2 diabetes，and the key targets were verified based on molecular docking technology.The Cytoscape 3.5.1 software was used to construct the network model of Sanhuang Decoction chemical composition-key gene.Results:There were 14 effective chemical composition of Sanhuang Decoction，30 corresponding target genes of type 2 diabetes，7 key target genes (NFKB1A，BCL2，TNF，RELA，TGFB1，PPARG，HMOX1) in Sanghuang Decoction.Through molecular docking，it was found that the chemical constituents of Sanhuang Decoction had a good binding effect with HMOX1，BCL2 and PPARγ.Conclusion:The molecular mechanism of Sanhuang Decoction for reducing blood sugar and lowering lipid was preliminarily explained，which provided theoretical guidance for further study on the selection of Sanhuang Decoction for the treatment of type 2 diabetes target genes.