| 引用本文:颜凯旋1,2,3，华爽1,2,3，吴小琴1,2,3，荣向路1,2,3，叶得伟1,2,3，郭姣1,2,3.基于新型代谢激素解析“枢纽肝”调节糖脂代谢的物质基础[J].世界中医药,2019,(01):. |
|
| 基于新型代谢激素解析“枢纽肝”调节糖脂代谢的物质基础 |
| Biological Exploration of “Nexus Liver” in Glucolipid Metabolic Disorders through Novel Metabolic Hormones |
| 投稿时间：2018-12-10 |
| DOI：10.3969/j.issn.1673-7202.2019.01.004 |
| 中文关键词: 枢纽肝 糖脂代谢病 代谢激素 中医证候物质基础 |
| English Keywords:Nexus liver Glucolipid metabolic disease Metabolic hormone Biological essence of Nexus Liver in traditional Chinese medicine |
| 基金项目:国家自然科学基金重点项目(81530102,81830113);广东省省级科技计划项目(2017B050504005);广东省科技厅实验室建设项目(2017B030314064);广东省科技厅国际合作基地建设项目(2016B050501003) |
| 作者 | 单位 | | 颜凯旋1,2,3，华爽1,2,3，吴小琴1,2,3，荣向路1,2,3，叶得伟1,2,3，郭姣1,2,3 | 1 教育部糖脂代谢病粤港澳联合实验室,广州,510006
2 广东省代谢病中西医结合研究中心,广州,510006
3 广东药科大学中医药研究院,广州,510006 |
|
| 摘要点击次数: 1178 |
| 全文下载次数: 1750 |
| 中文摘要: |
| “枢纽肝代谢稳态调节系统”是郭姣教授率团队基于系统梳理水谷津液代谢的中医经典文献,并结合30余年的临床研究结果提出的创新理论。该理论突破既往代谢性疾病多从脾肾论治的认识局限,强调“肝”是调控气血津液运化的枢纽,“枢纽肝代谢稳态调节系统”功能失调是糖脂代谢病发生的核心病机。基于该认识的“调肝启枢化浊法”及代表方药对于代谢性疾病具有较好疗效。现代生物学研究结果已明确,肝脏可通过FGF21、Adiponectin等新型代谢激素对糖脂代谢发挥重要调控作用。本文旨在从代谢调节激素角度探讨“枢纽肝”调节糖脂代谢的物质基础,对于阐明“枢纽肝代谢稳态调节系统”生物学本质以及糖脂代谢病中医核心病机的病理实质具有重要意义。 |
| English Summary: |
| “Nexus Liver” is an innovative theory raised by Pro. Guo Jiao，who analyzed classic of traditional Chinese medicine in metabolite selected by her team's and combined her clinical researches in the past 30 years. This theory breaks the limits of therapies for metabolic diseases，and it emphasizes liver as the core，rather than just from the aspect of spleen and kidney. Dysfunction of “the metabolism adjusting system of the liver” is the vital pathological mechanism for glycolipid metabolism disese (GLMD). The therapies based on it are effective for metabolic disease. The results of modern biological researches indicate that liver influences the process of glucose and lipid metabolism through new metabolic hormones like FGF21 and Adiponectin. This article aims to discuss the material base of “liver as a core”. It is meaningful for figuring out the bio-essence of “the metabolism adjusting system of the liver” and vital Chinese Medicine pathological substance in GLMD. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
