世界中医药
文章摘要
引用本文:陈仁波1,盖国忠1,谢雁鸣1,张文丽2,庄严3.应用倾向性评分方法分析脉血康胶囊对缺血性脑血管病治疗结局的影响[J].世界中医药,2019,(01):.  
应用倾向性评分方法分析脉血康胶囊对缺血性脑血管病治疗结局的影响
Analysis of the Effects of Maixuekang Capsule on the Outcome of Ischemic Cerebrovascular Disease by the Application of Propensity Score Method
投稿时间:2017-10-24  
DOI:10.3969/j.issn.1673-7202.2019.01.021
中文关键词:  倾向性评分  脉血康胶囊  缺血性脑血管病  电子病历  治疗结局  真实世界
English Keywords:Propensity score  Maixuekang capsule  Ischemic cerebrovascular disease  Electronic medical record  Treatment outcome  Real world
基金项目:国家中医药行业专项(201507003-8);国家“重大新药创制”科技重大专项(2015ZX09501004-001-002、2015ZX09501004-001-009);北京市中医药科技发展专项(JJ2014-53);中国中医科学院自主选题项目(PY1303)
作者单位
陈仁波1,盖国忠1,谢雁鸣1,张文丽2,庄严3 1 中国中医科学院中医临床基础医学研究所北京100700 2 中国人民大学统计学院北京100872 3 解放军海军总医院北京100048 
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中文摘要:
      目的:探讨脉血康胶囊治疗缺血性脑血管病的治疗结局,了解脉血康胶囊对缺血性脑血管病治疗结局的影响,为临床合理用药提供借鉴。方法:选取基于全国20家大型三级甲等医院的电子医疗病历数据库,对使用和未使用脉血康胶囊的缺血性脑血管病患者按照一定的标准进行1:1匹配。将数据库中治疗结局为“痊愈”和“好转”的重新合并定义为治疗有效,将“无效”“死亡”和“其他”合并为治疗无效人群,通过倾向性评分的方法对重新合并后2组的治疗结局有效性进行比较。结果:匹配后使用脉血康胶囊患者组(A组)与未使用脉血康胶囊(B组)均为2 449例。在未控制混杂因素的情况下,2组的有效率差异有统计学意义(P<0.05),A组较B组治疗效果好。通过3种Logistic回归分析方法分别进行了分析,均显示回归系数大于0,且差异有统计学意义(P<0.05)。结论:使用脉血康胶囊的缺血性脑血管病患者较不使用该药的缺血性脑血管病患者的治疗有效率高,能提高缺血性脑血管病患者的临床疗效。
English Summary:
      Based on the hospital electronic medical record database,to discuss the treatment outcome of the ischemic cerebrovascular disease with Maixuekang capsule,find out the effects of Maixuekang capsule on the treatment outcome of ischemic cerebrovascular disease,and provide reference for clinical rational drug use.Methods:This study was based on the database of electronic medical records of 20 large-scale tertiary-level hospitals across the country,and 1:1 matching of patients with ischemic cerebrovascular disease who used and not used Maixuekang capsules according to certain standards.Recombination of treatment outcomes in the database with “recovery” and “improvement” were defined as treatment effectiveness,“invalidity”“death”,and “other” were merged into treatment-ineffective populations.The efficacy of the group's treatment outcomes was compared by propensity scores.Results:After matching,A group included 2449 cases treated with Maixuekang capsule and B group also included 2449 cases treated with Maixuekang capsule.The simple chi-square test results showed that the effective rate of the two groups had significant statistical difference(P<0.05)in the absence of controlled confounding factors,and the treatment effect of group A was better than that of group B.Three logistic regression analysis methods were used for analysis.All showed that the regression coefficient was greater than 0,and all had statistical significance(P<0.01).Conclusion:Patients with ischemic cerebrovascular disease who used Maixuekang capsules are more effective than that those do not use this drug,and can improve the clinical efficacy of patients with ischemic cerebrovascular disease.
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