世界中医药
文章摘要
引用本文:庞海江1,许家艳1,丁守坤2.益气活血解毒方联合西药治疗幽门螺杆菌阳性慢性萎缩性胃炎患者的疗效及对胃蛋白酶原的影响[J].世界中医药,2019,(01):.  
益气活血解毒方联合西药治疗幽门螺杆菌阳性慢性萎缩性胃炎患者的疗效及对胃蛋白酶原的影响
Curative Effects of Yiqi Huoxue Jiedu Decoction Combined with Western Medicine on Patients with Hp Positive Chronic Atrophic Gastritis and Its Effects on Pepsinogen
投稿时间:2018-12-05  
DOI:10.3969/j.issn.1673-7202.2019.01.025
中文关键词:  益气活血解毒方  四联疗法  幽门螺杆菌  慢性萎缩性胃炎  疗效  胃蛋白酶原  炎性反应递质  血液流变学
English Keywords:Yiqi Huoxue Jiedu Decoction  Quadruple therapy  Positive helicobacterpylor  Chronic atrophic gastritis  Curative effects  Pepsinogen  Inflammatory factors  Hemorheology
基金项目:二〇一七年度河南省医学科技攻关计划项目(21702213)——房颤行左心耳封堵术后与单纯抗凝治疗后血栓发生风险对比
作者单位
庞海江1,许家艳1,丁守坤2 1 河南省郑州市中医院急诊科郑州450007 2 河南省人民医院心内科郑州450003 
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中文摘要:
      目的:探究益气活血解毒方联合西药治疗幽门螺杆菌(Hp)阳性慢性萎缩性胃炎(CAG)患者的疗效及对胃蛋白酶原(PG)的影响。方法:选取2016年11月至2018年2月郑州市中医院收治的Hp阳性CAG患者74例,随机分为对照组和观察组,每组37例。对照组Hp阳性CAG患者采用四联疗法治疗,观察组Hp阳性CAG患者在对照组的基础上服用益气活血解毒方。治疗3个月后,检测患者PG(PGⅠ、PGⅡ、PGⅠ/PGⅡ)、炎性反应递质水平、胃液pH值以及血液流变学指数变化情况,评价其疗效。结果:观察组总有效率为94.59%,对照组总有效率为72.97%(P<0.05)。治疗后,2组患者的pH值、炎性反应递质水平[(白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-)、超敏C反应蛋白(hs-CRP)]、血液流变学指数(全血黏度高切、全血黏度低切、血浆黏度、红细胞聚集指数)均降低,PG(PGⅠ、PGⅡ、PGⅠ/PGⅡ)水平升高(P<0.05),观察组患者的pH值、炎性反应递质水平(IL-6、TNF-、hs-CRP)、血液流变学指数(全血黏度高切、全血黏度低切、血浆黏度、红细胞聚集指数)低于对照组,PG(PGⅠ、PGⅡ、PGⅠ/PGⅡ)水平高于对照组(P<0.05)。结论:益气活血解毒方联合西药四联疗法可以对Hp产生抑菌作用,有效控制Hp阳性CAG患者的PG、炎性反应递质水平,改善血流动力学,保护胃黏膜,发挥良好的疗效,具有较高的临床应用价值。
English Summary:
      To explore the curative effects of Yiqi Huoxue Jiedu Decoction combined with western medicine on patients with helicobacter pylori (Hp) positive chronic atrophic gastritis (CAG) and its effects on pepsinogen (PG). Methods:A total of 74 patients with Hp positive CAG treated in Zhengzhou Hospital of Traditional Chinese Medicine from November 2016 to February 2018 were selected and randomly divided into the control group and the observation group,with 37 patients in each group. The patients with Hp positive CAG in the control group were treated with quadruple therapy. The patients with Hp positive CAG in the observation group were treated with Yiqi Huoxue Jiedu Decoction on the basis of the same treatment in control group. After 3 months of treatment,the levels of PG (PGI,PGII,PGI/PGII),inflammatory factors and blood rheological index were measured to evaluate the efficacy. Results:The total effective rate was 94.59% in the observation group and 72.97% in the control group (P<0.05). After treatment,the levels of pH,inflammatory factors (IL-6,TNF,CRP),blood rheological index (whole blood viscosity high shear,whole blood viscosity low shear,plasma viscosity,erythrocyte aggregation index) decreased,and the levels of PGI,PGII,PGI/PGII increased in both groups (P<0.05),and the levels of pH,inflammatory factors (IL-6,TNF,CRP),blood rheological index (whole blood viscosity high shear,whole blood viscosity low shear,plasma viscosity,erythrocyte aggregation index) in the observation group were lower than those in the control group,the levels of PGI (PGI,PGII,PGI / PGII) were higher than the control group (P<0.05). Conclusion:Yiqi Huoxue Jiedu Decoction combined with western medicine quadruple therapy has bacteriostatic effects on Hp,and it can effectively control the levels of PG and inflammatory factors in Hp positive CAG patients,improve hemodynamics,protect gastric mucosa,which has a good therapeutic effect with high clinical value.
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