To investigate the effects of Chuankezhi injection combined with budesonide aerosol in the treatment of acute attack of bronchial asthma and its influence on inflammatory mediators and pulmonary function.Methods:A total of 84 patients with acute attack of asthma in the First People's Hospital of Ziyang from December 2014 to December 2016 were divided into control group and observation group with 42 cases in each group according to random table method.The observation group was treated with Chuankezhi injection combined with budesonide aerosol.The control group was only treated with budesonide aerosol.The two groups were treated for 7 days.The two groups were compared with the main symptoms and signs score, inflammatory mediators and pulmonary function changes before and after treatment.Results:The total efficiency of the observation group (92.86%) was higher than the control group (69.05%) (P<0.05) with statistically significance.The phlegm, wheezing, cough, wheezing score in the observation group were lower than the control group (P<0.05).Interleukin-4 (IL-4) and immunoglobulin E (IgE) levels after treatment in the observation group were lower than that of control group, but Interferon-γ (IFN-γ) level was higher than that of control group with statistically significance (P<0.05).The forced expiratory volume in one second (FEC1) for predicted value, forced vital capacity and peak expiratory flow in the observation after treatment was higher than that of control group (P<0.05).Conclusion:The treatment of acute attack of bronchial asthma with Chuankezhi injection combined with Budesonide Aerosol is effective, and it can improve the inflammatory mediators and lung function, which has important research significance.