| 引用本文:彭仁德1，金涛2.中药排石汤联合体外震波碎石术对肾结石患者肾功能、尿液代谢的影响[J].世界中医药,2019,(01):. |
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| 中药排石汤联合体外震波碎石术对肾结石患者肾功能、尿液代谢的影响 |
| Effects of Chinese Medicine Paishi Decoction Combined with Extracorporeal Shock Wave Lithotripsy on the Renal Function and Urine Metabolism of Patients with Renal Calculus |
| 投稿时间：2018-10-29 |
| DOI：10.3969/j.issn.1673-7202.2019.01.033 |
| 中文关键词: 肾结石 体外震波碎石术 排石汤 肾功能 尿液代谢 |
| English Keywords:Renal calculus Extracorporeal shock wave lithotripsy Paishi Decoction Renal functions Urine metabolism |
| 基金项目:2015年四川省中医药管理局课题（2016Q042） |
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| 中文摘要: |
| 目的：探讨中药排石汤联合体外震波碎石术（ESWL）对肾结石患者肾功能、尿液代谢的影响。方法:选取2014年5月至2017年2月成都市龙泉驿区中医医院收治的肾结石患者138例为研究对象，按照随机数字表法分为观察组和对照组，每组69例，2组均行ESWL治疗，术后对照组采用常规药物治疗，观察组在对照组的基础上采用中药排石汤治疗，2组治疗时间均为2周。比较2组患者临床疗效及中医证候改善情况；统计手术前后2组患者肾功能及尿液代谢状况。结果：术后观察组总有效率为94.20%，显著高于对照组的78.26%（P<0.05）；与术前比较，2组患者中医证候积分均下降，且观察组低于对照组（P<0.05）；与术前比较，术后3~14 d 2组血清血肌酐（SCr）、尿素氮（BUN）、半胱氨酸蛋白酶抑制剂（Cys-C）、中性粒细胞明胶酶相关载脂蛋白（NGAL）水平均呈先升高后降低趋势，且各时间点观察组均低于对照组（P<0.05）；术后14 d观察组与术前比较，差异无统计学意义（P>0.05），对照组仍高于术前（P<0.05）；与术前比较，术后2周内2组患者高尿钙症、高草酸尿症、高尿酸尿症、低尿量及低镁尿症等尿液代谢异常发生率下降（P<0.05），且观察组低于对照组（P<0.05）。结论：中药排石汤联合ESWL治疗肾结石可保护患者肾功能，降低尿液代谢异常状况发生率，临床疗效显著。 |
| English Summary: |
| To explore the influence of Chinese medicine Paishi Decoction combined with extracorporeal shock wave lithotripsy (ESWL) on the renal function and urine metabolism of patients with renal calculus. Methods:A total of 138 cases of patients with renal calculus from May 2014 to February 2017 were selected as study objects and were randomly divided into observation group (n=69) and control group (n=69). The 2 groups were treated with ESWL，control group was treated with routine drugs，and the observation group was treated with Paishi Decoction on the basis of control group. The 2 groups were treated for 2 weeks. The clinical efficacy and the improvement of Traditional Chinese Medicine syndrome of 2 groups were compared; the renal function index and urine metabolism condition of 2 groups were detected before and after operation. Results:The total effective rate of observation group reached up to 94.20% after operation，which was higher than that 78.26% of control group (P<0.01); Compared with before operation，the Traditional Chinese Medicine syndrome integral of 2 groups decreased after operation，and observation group were lower than control group (P<0.01); Compared with before operation，the levels of serum SCr，BUN，NGAL，Cys-C of 2 groups from 3 days to 14 days after operation increased firstly and then decreased，and observation group was lower than control group at each time point (P<0.01); There was no difference between 14 days after operation and before operation of observation group (P>0.05)，but the control group was higher than those before operation (P<0.01). Compared with before operation，the incidence of urinary metabolic abnormalities such as high urinary calcium，phenylketonuria，hyperuricemia，low urine output and low magnesium decreased within 2 weeks after operation (P<0.05 or P<0.01)，and observation group were lower than control group (P<0.01). Conclusion:Chinese medicine Paishi Decoction combined with ESWL in the treatment of renal calculus can protect the renal function of patients，reduce the incidence of urinary metabolic abnormalities，the clinical efficacy is remarkable. |
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