世界中医药
文章摘要
引用本文:邓家侵1,何伟1,危建安2,刘全知1,伍慧媚1.银屑灵片对银屑病肥胖患者血清瘦素动态表达的干预作用[J].世界中医药,2019,(01):.  
银屑灵片对银屑病肥胖患者血清瘦素动态表达的干预作用
Intervention Effects of Yinxieling Tablets on Leptin Expression of Obese Patients with Psoriasis Vulgaris
投稿时间:2018-03-30  
DOI:10.3969/j.issn.1673-7202.2019.01.034
中文关键词:  银屑病  肥胖  血热证  银屑灵片  复方丙酸氯倍他索软膏  瘦素  作用机制  中西医结合
English Keywords:Psoriasis  Obesity  Blood heat syndrome  Yinxieling Tablets  Compound chlorbetasol propionate ointment  Leptin  Mechanism of action  Integration of traditional Chinese and western medicine
基金项目:2016年广东省中医药局科研项目(20161105)
作者单位
邓家侵1,何伟1,危建安2,刘全知1,伍慧媚1 1 广东省中医院皮肤科广州510120 2 广东省中医院分子生物学研究室广州510120 
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中文摘要:
      目的:观察银屑灵片对寻常型银屑病肥胖患者血清瘦素动态表达的干预作用。方法:选取2017年3月至2017年6月广东省中医院收治的男性银屑病患者60例,按照随机数字表法随机分为对照组和观察组,每组30例。对照组患者外用复方丙酸氯倍他索软膏,观察组患者在对照组的基础上同时口服银屑灵片,连续用药2个月。观察2组临床治疗有效率,治疗后1、2个月评价中医证候积分、皮损程度及体重指数(BMI),以及血清瘦素的动态表达情况。结果:观察组有效率93.3%,较对照组的73.3%明显升高(P<0.05);治疗后1、2个月2组患者中医证候积分、BMI与皮损PASI评分均较治疗前明显下降(均P<0.05),且治疗2个月的中医证候积分、BMI与皮损PASI评分显著低于治疗后1个月(P<0.05),组间比较以观察组的下降程度更显著(P<0.05);治疗2个月后,2组患者血清瘦素水平均较治疗前有所下降(P<0.05),且显著低于治疗后1个月(P<0.05),组间比较以观察组的下降程度更显著(P<0.05)。结论:银屑灵片可改善患者的临床症状,降低BMI,减轻银屑病皮损斑块的严重程度,其机制可能是通过调控瘦素水平以调节机体的代谢状态,通过调节瘦素水平从而降低IFN-γ水平,达到治疗银屑病的目的。
English Summary:
      To observe the effects of Yinxieling Tablet on the dynamic expression of leptin in the serum of obese patients with psoriasis vulgaris. Methods:A total of 60 patients with psoriasis vulgaris in Guangdong Provincial Hospital of Chinese Medicine from March 2017 to June 2017 were randomly divided into observation group (n=30) and control group (n=30). Control group patients were treated with compound clobetasol propionate ointment,and observation group patients received oral Yinxieling Tablets combined with the same external medication for two months. The efficacy of the two groups was observed and the dynamic expression of traditional Chinese medicine (TCM) syndromes score,skin lesion degree,body mass index (BMI),and serum leptin were evaluated at one month and two months after treatment. Results:The effective rate of the observation group was 93.3%,which was significantly higher than that of the control group (73.3%,P<0.05). The scores of TCM syndromes,BMI and PASI of skin lesions in the two groups were significantly lower than those before treatment after treatment (P<0. 05). The serum leptin levels in both groups were lower than those before treatment (P<0.05). The serum leptin level after 2 months treatment was significantly lower than that at 1 month after treatment (P<0.05),and the decrease of serum leptin level was more significant in the observation group than in the observation group (P<0.05). Conclusion:Yinxieling Tablets can significantly improve the clinical symptoms of patients and reduce the severity of psoriatic plaques and lower BMI. The mechanism may lie in regulating the metabolic state of the body by reducing leptin levels and decreasing IFN-γ level.
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