| 引用本文:吕树泉1，2，宋慧丽1，韩中千1，张淑芳1，苏秀海1，2，王元松1，于文霞1，2，刘爱茹1.健脾固肾化瘀组方联合雷公藤多苷片对临床期糖尿病肾病临床疗效及肾脏纤维化指标的影响[J].世界中医药,2019,(01):. |
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| 健脾固肾化瘀组方联合雷公藤多苷片对临床期糖尿病肾病临床疗效及肾脏纤维化指标的影响 |
| Study on the Clinical Effects of Jianpi Gushen Huayu Formula Combined with Tripterygium Glycosides Tablets on Clinical Diabetic Nephropathy Treated and Influences on Renal Fibrosis Indexes |
| 投稿时间：2017-11-19 |
| DOI：10.3969/j.issn.1673-7202.2019.01.036 |
| 中文关键词: 健脾固肾化瘀组方 临床期糖尿病肾病 雷公藤多苷片 尿蛋白 肾脏纤维化 名老中医 经验 |
| English Keywords:Jianpi Gushen Huayu formula Clinical diabetic nephropathy Tripterygium glycosides tablet Urinary protein Renal fibrosis Old Chinese medicine practitioners Experience Summary |
| 基金项目:河北省中医药管理局省级科研计划项目(2016268)——健脾固肾化瘀组方治疗临床期糖尿病肾病（脾肾两虚夹瘀型）临床疗效观察 |
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| 中文摘要: |
| 目的：观察健脾固肾化瘀组方治疗临床期糖尿病肾病患者的临床疗效以及其对肾脏纤维化相关指标的影响。方法：选取2015年12月至2016年12月沧州中西医结合医院门诊及病房的临床期糖尿病肾病患者100例，随机平均分为2组，对照组50例患者在常规治疗的基础上加用雷公藤多苷片（20 mg/次，口服，3次/d）治疗，观察组50例患者在对照组治疗的基础上加用健脾固肾化瘀组方，1次/d，2组患者均以4周为1疗程，治疗3个疗程后统计2组患者的尿蛋白定量、肌酐（Scr）、胱抑素C（CysC）、基质金属蛋白酶抑制剂-1（TIMP-1）、转化生长因子-β1（TGF-β1）、Ⅳ型胶原（CⅣ）指标以及临床疗效与不良反应。结果：观察组患者治疗后的尿蛋白、Scr、CysC、TIMP-1、TGF-β1、CⅣ明显低于治疗前与对照组治疗后（P<0.05）。观察组患者治疗总有效率明显高于对照组（P<0.05）。结论：健脾固肾组方联合雷公藤多苷片治疗临床期糖尿病肾病，能够有效降低尿蛋白，还可以有效改善血清肾功能指标与肾脏纤维化指标，具有良好的临床效果。 |
| English Summary: |
| To observe clinical effects of Jianpi Gushen Huayu Formula on diabetic nephropathy in clinical stage and renal fibrosis related indexes.Methods:A total of 100 cases with clinical stage of diabetic nephropathy in outpatient department and ward from December 2015 to December 2016 were randomly divided into 2 groups,with 50 cases in each group.Control group treated with Tripterygium Glucosides dispersible tablets on the basis of routine treatment(oral administration,20 mg each time,3 times a day),while the treatment group was additionally treated with Jianpi Gushen Huayu Formula(1 time a day),with 4 weeks as 1 course of treatment.Urinary protein,serum creatinine(Scr),Cystatin C(CysC),tissue inhibitor of metalloproteinase-1(TIMP-1)and transforming growth factor β1(TGF-β1),type IV collagen(C IV)index,clinical curative effects and adverse reactions of 2 groups after treatment of 3 courses were calculated.Results:After treatment,urinary protein,Scr,CysC,TIMP-1,TGF-β1 and C IV in the treatment group were significantly lower than those before treatment and that of control group(P<0.05).The total effective rate of treatment group was significantly higher than that of control group(P<0.05).Conclusion:Jianpi Gushen formula combined with tripterygium glycosides tablets in the treatment of clinical stage of diabetic nephropathy,can effectively reduce the urinary protein,but also can effectively improve the serum indexes of renal function and renal fibrosis index,which has good clinical effects. |
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