世界中医药
文章摘要
引用本文:王涛,胡维,李剑,康汇,陈旭旭.电针、穴位注射用药在胸腰椎压缩性骨折中的应用[J].世界中医药,2019,(01):.  
电针、穴位注射用药在胸腰椎压缩性骨折中的应用
Electroacupuncture and Acupoint Injection for the Treatment of Thoracolumbar Vertebral Compression Fracture
投稿时间:2018-07-31  
DOI:10.3969/j.issn.1673-7202.2019.01.040
中文关键词:  电针  穴位  胸腰椎压缩性骨折  骨密度  皮内素  骨转换生化标志  ET  临床测评
English Keywords:Electroacupuncture  Acupoints  Thoracolumbar vertebral compression fracture  Bone mineral density  Intradermal hormone  Bone conversion biochemical marker  ET  Clinical evaluation
基金项目:陕西省卫生厅卫生科研基金项目(16D42)
作者单位
王涛,胡维,李剑,康汇,陈旭旭 西安交通大学医学部附属红会医院西安710054 
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中文摘要:
      目的:测评电针、穴位注射用药治疗胸腰椎压缩性骨折对患者BMD、ET、MMP-2、MMP-9以及骨转换生化标志物影响。方法:回顾性抽取2017年1月至2017年9月西安交通大学医学部附属红会医院收治的胸腰椎压缩性骨折患者131例,依据不同的用药方式分成观察组66例与对照组65例。观察组采用电针、穴位注射骨肽注射液,对照组采用静脉点注的方式使用该药物。治疗4、12和28周时检测2组患者BMD、ET、MMP-2、MMP-9以及骨转换生化标志物指标,评价不同用药方式对各项指标的影响。结果:1)与对照组比较,观察组患者骨密度:第4周(1.04±0.17)g/cm2;12周(1.43±0.28)g/cm2;28周(1.76±0.22)g/cm2。观察组患者第4周皮内素为(3.85±0.57)ng/L,12周皮内素为(2.79±0.52)ng/L,28周皮内素为(1.83±0.34)ng/L。观察组各时间点BMD与ET水平与对照组比较,差异均有统计学意义(均P<0.05)。2)采用电针、穴位注射用药的患者血清水平明显优于采用常规使用骨肽注射液的患者,MMP-2、MMP-9水平能够在28周内恢复至正常水平。3)28周治疗结束后,观察组PINP(73.69±17.17)μg/mL,PICP(98.25±24.07)μg/mL,BALP(33.45±6.02)U/L;对照组PINP(65.38±26.39)μg/mL,PICP(83.88±19.64)μg/mL,BALP(25.74±4.95)U/L。2组比较差异有统计学意义(P<0.05)。结论:电针、穴位注射用药治疗胸腰椎压缩性骨折,对患者BMD、ET、MMP-2、MMP-9以及骨转换生化标志物改善优势明显。
English Summary:
      Objective To evaluate the effect of electroacupuncture and acupoint injection on BMD,ET,MMP-2,MMP-9 and bone biochemical markers in the treatment of thoracolumbar vertebral compression fracture. Methods:From January 2017 to September 2017,170 cases of patients with thoracolumbar vertebral compression fracture admitted in Xi'an Honghui Hospital Affiliated to Xi'an Jiaotong University Health Science Center were selected retrospectively. According to different medication methods,they were randomly divided into Traditional Chinese Medicine (TCM) group (n=86) and routine group (n=84). Patients in TCM group were treated with electroacupuncture and acupoint injection,while patients in routine group were treated with intravenous injection of the same drug. After the course of treatment,according to the indexes of BMD、ET、MMP-2、MMP-9 and biochemical markers which were measured 4 weeks,12 weeks and 27 weeks after the treatment,the effects of different medication methods on patients were evaluated. Results:1) The bone mineral density (BMD) in TCM group:at the 4th week,the T value was (-1.29±0.17),Z value was (-1.84±0.35); at the 12th week the T value was (-0.63±0.28) and Z value was (-1.35±0.27); at the 27th week,the T value was (0.52±0.22) and Z value was (-0.96±0.25). In the TCM group,at the 4th week,the intradermal hormone was (3.85±0.57) ng/L,at the 12th week,the intradermal hormone was (2.79±0.52) ng/L,at the 27th week,the intradermal hormone was (1.83±0.34) ng/L. Compared with the routine group,there were obvious advantages in those indexes. 2) For the patients who were treated with electroacupuncture and acupoint injection,their serum level was significantly higher than that in the patients treated with conventional Western medicine orally. The levels of MMP-2 and MMP-9 can return to normal level within 27 weeks. 3) After 27 weeks,the biochemical markers of bone turnover were detected in the two groups. In the TCM group,PINP was (73.69±17.17) μg/mL,PICP was(98.25±24.07)μg/mL,BALP was(33.45±6.02)U/L,APTT was (34.45±6.02)s; In the routine group,PINP was(65.38±26.39)μg/mL,PICP was(83.88±19.64)μg/mL,BALP was(25.74±4.95)U/L,APTT was(25.74±4.59)s. Conclusion:For the treatment of thoracolumbar vertebral compression fracture,the electroacupuncture and acupoint injection have obvious effects on BMD、ET、MMP-2、MMP-9 and biochemical markers of bone turnover. It is worthy of extensive clinical application.
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