| 引用本文:李淼，安红梅，沈克平，胡兵.蛇莓抗肿瘤作用及临床应用[J].世界中医药,2019,(02):. |
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| 蛇莓抗肿瘤作用及临床应用 |
| Anti-cancer effects of Herba Duchesnea Indica and Its Clinical Application |
| 投稿时间：2018-03-28 |
| DOI：10.3969/j.issn.1673-7202.2019.02.054 |
| 中文关键词: 蛇莓 化学成分 恶性肿瘤 中药药理 临床应用 中药复方 中成药 发明专利 |
| English Keywords:Herba Duchesnea Indica Chemical components Cancer Pharmacology of traditional Chinese medicine Clinical application Herbal formula Chinese patent drug Patent |
| 基金项目:国家自然科学基金项目（81473625）;上海市科技支撑项目（16401902500）；龙华医院科技创新项目（CX201756） |
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| 中文摘要: |
| 蛇莓是蔷薇科植物蛇莓Duchesnea indica（Andr.）Focke的干燥全草，可以清热解毒、散瘀消肿、凉血止血。蛇莓主要成分包括蛇莓苷A、蛇莓苷B、乌苏酸、齐墩果酸、β-谷甾醇、蔷薇酸、对羟基桂皮酸和芹菜素等。蛇莓可以抑制肿瘤细胞增殖和生长，阻滞细胞周期，激发细胞凋亡和失巢凋亡，抑制上皮-间质转化和血管生成；并可改善免疫功能。现代中医发展了16项含有蛇莓的发明专利，以及养正消积胶囊、藤龙补中汤、金龙胶囊、抑瘤宁、青消方和益气解毒汤等含有蛇莓的抗癌中药复方/中成药。蛇莓已用于脑瘤、鼻咽癌、肺癌、乳腺癌、食管癌、胃肠癌、肝癌、胰腺癌、膀胱癌、前列腺癌、宫颈癌、卵巢癌和肉瘤等多种恶性肿瘤的治疗。 |
| English Summary: |
| Herba Duchesnea Indica is the dried whole plant of Duchesnea indica (Andr.) Focke.The efficacy of Herba Duchesnea Indica are heat-clearing and detoxicating，dissipating stasis and detumescence，and cooling blood and hemostasis.The main compounds of Herba Duchesnea Indica include ducheside A and B，ursolic acid，oleanolic acid，β-sitosterol，rosolic acid，p-hydroxycinnamic acid and apigenin.Herba Duchesnea Indica can inhibit cancer cell proliferation and tumor growth，arrest cell cycle，induce apoptosis and anoikis，inhibit epithelial-mesenchymal transition and angiogenesis，and improve immune function.Contemporary physician of traditional Chinese medicine have developed 16 anti-cancer patents which contain Herba Duchesnea Indica，including Yangzheng XiaoJi Capsule，Tenglong Buzhong Decoction，Jinlong Capsule，Yiliuning，Qingxiaofang and Yiqi Jiedu Decoction.Herba Duchesnea Indica has been used for various cancer treatment，including brain tumors，nasopharyngeal cancer，lung cancer，breast cancer，esophageal cancer，gastrointestinal cancer，liver cancer，pancreatic cancer，bladder cancer，prostate cancer，cervical cancer，ovarian cancer and sarcoma. |
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