| 引用本文:孙静1，赵荣华1，毛鑫1，郭姗姗1，高英杰1，姚荣妹1，董秀2，吴昌标2，崔晓兰1.开喉剑喷雾剂治疗急性咽炎的用法用量研究[J].世界中医药,2019,(03):. |
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| 开喉剑喷雾剂治疗急性咽炎的用法用量研究 |
| Study on the Usage and Dosage of Kaihoujian Spray in the Treatment of Acute Pharyngitis |
| 投稿时间：2018-09-20 |
| DOI：10.3969/j.issn.1673-7202.2019.03.012 |
| 中文关键词: 开喉剑喷雾剂；急性咽炎；乙型溶血性链球菌；用法用量 大鼠 |
| English Keywords:Kaihoujian Spray Acute pharyngitis Hemolytic streptococcal type B Usage and dosage Rats |
| 基金项目:国家自然科学基金项目（81774204） |
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| 中文摘要: |
| 目的:探讨开喉剑喷雾剂治疗急性咽炎的最佳用法用量，为临床应用提供依据。方法:选取10%氨水咽部喷雾及乙型溶血性链球菌菌液感染2种方法造成大鼠急性咽炎模型，设置4~10喷/次，6~10次/d,共12个给药组，评价开喉剑喷雾剂的最佳用法用量。结果:开喉剑喷雾剂各给药组均可不同程度减轻大鼠咽部肉眼病变及镜下组织病变，药效稳定剂量范围为6~10喷/次、8~10次/d。结论:开喉剑喷雾剂治疗大鼠急性咽炎模型的最佳剂量范围为6~10喷/次、8~10次/d。 |
| English Summary: |
| To explore optimum usage and dosage of Kaihoujian Spray treating acute pharyngitis and provide references for clinical use. Methods:A total of 12 groups were given Kaihoujian Spray with 4-10 sprays/times，6-10 times/day，then evaluated the best usage and dosage of Kaihoujian Spray on rat acute pharyngitis model induced by 10% ammonia liquor by throat spray and hemolytic streptococcal type B by infection. Results:All the 12 treatments could alleviate the pharyngeal naked-eye and microscopic lesions in rats and the stable dose range was 6-10 sprays/times，8-10 times/day. Conclusion:The best dose range of Kaihoujian Spray in the treatment of acute pharyngitis in rats was 6~10 sprays/times，8~10 times/day. |
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