世界中医药

目的：研究尝试以网络药理学的方法对肝经中药及治疗疾病的关系进行研究，探索网络药理学研究中药归经的可能性。方法：选取从分子对接筛选出2015版《中华人民共和国药典》中肝经中药的活性靶点，并寻找中药归经与疾病的共同活性靶点，通频次频率的统计分析，探索中药归经与治疗疾病的关系。结果：肝经中药蛋白靶点在精神和行为障碍疾病、血液及造血器官疾病和涉及免疫机制的某些疾患，妊娠、分娩和产褥期相关疾病上有较高频率的分布。结论：在网络药理学基础上得到的肝经中药与治疗疾病的关系与中医基础理论中肝的生理功能有一定关联。

English Summary:

The study of meridian tropism has great significance to the development of Chinese herbal medicine theory. In recent years network pharmacology had been widely used in the study of traditional Chinese medicine(TCM). This study aims to explore the relationship between liver meridian and treatment based on network pharmacology for the possibility of meridian tropism theory adopting network pharmacology. Methods:Molecular docking was used to screen the active targets of Chinese medicine of liver meridian in Pharmacopoeia of the People's Republic of China(2015). Common active targets were searched between Chinese medicine of liver meridian and diseases. The frequency of Chinese medicine and protein with liver meridian in different disease would be analyzed to explore the relationship between tropism and indication. Results:The albumen targets of Chinese medicine of liver meridian has a high frequency in the diseases of mental and behavioural disorders，diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism，pregnancy，childbirth and the puerperium. Conclusion:The relationship between treatment and Chinese medicine of liver tropism based on network pharmacology is related to physiological function of liver.

查看全文查看/发表评论下载PDF阅读器