| 引用本文:董远1，来要良2，马致洁1，刘永2，赵奎君1.珍珠烫伤膏干预小鼠溃疡性结肠炎的作用研究[J].世界中医药,2019,(03):. |
|
| 珍珠烫伤膏干预小鼠溃疡性结肠炎的作用研究 |
| Therapeutic Effects of Pearl Scald Ointment in Rats with Ulcerative Colitis |
| 投稿时间：2018-12-13 |
| DOI：10.3969/j.issn.1673-7202.2019.03.017 |
| 中文关键词: 珍珠烫伤膏 溃疡性结肠炎 灌肠疗法 葡聚糖硫酸钠 美沙拉嗪 疾病活动指数 肿瘤坏死因子 白细胞介素-6 中药 |
| English Keywords:Pearl Scald Ointment Ulcerative colitis Enema therapy Dextran Sulfate Sodium Mesalazine Disease activity indexes Tumor necrosis factor Interleukin-6 Herbal medicine |
| 基金项目:中国中医科学院基本科研业务费自主选题项目（ZZ10-018-10）——治疗抗生素性腹泻的有效中药筛选与评价 |
|
| 摘要点击次数: 716 |
| 全文下载次数: 732 |
| 中文摘要: |
| 目的：探讨珍珠烫伤膏对葡聚糖硫酸钠(Dextran Sulfate Sodium，DSS)诱导小鼠肠道炎性反应的疗效。方法：采用DSS诱导的小鼠溃疡性结肠炎（Ulcerative Colitis，UC）模型，随机分为空白组、模型组、美沙拉嗪(Mesalazine，Mes)组和珍珠烫伤膏（Pearl Scald Ointment，Pso）低（Pso1）、高剂量组（Pso2），每组10只。给药10 d，观察并分析小鼠体质量、结肠长度、病理评分及炎性反应因子等方面的变化。结果：与模型组比较，珍珠烫伤膏各剂量组小鼠的疾病活动指数、结肠病变评分、HE染色病变评分及炎性反应因子水平均显著下降，由UC引起的体质量及结肠长度缩短均有所改善，差异有统计学意义（P<0.05）。结论：珍珠烫伤膏对DSS诱导的溃疡性结肠炎有显著地改善作用，提示其对溃疡性结肠炎有一定的治疗作用。 |
| English Summary: |
| To explore the therapeutic effects of Pearl Scald Ointment in rats with ulcerative colitis(UC)induced by dextran sulfate sodium(DSS). Methods:The UC rats induced by DSS were randomly divided into the normal control(NC)group，model group，Mesalazine(Mes)group，low and high dose groups of Pearl Scald Ointment(Pso)with 10 rats per group. After administration for 10 days，the changes of body weight，colon length，pathological scores and inflammatory factors in rats were observed and analyzed. Results:Compared with the model group，the disease activity indexes，colon lesion scores，HE staining lesion scores and levels of inflammatory factors of rats in each dose group of Pso were significantly decreased. The body weight and shorted colon length caused by UC were improved with statistically significant differences(P<0.05). Conclusion:Pso has significant improvement effects on rats with UC induced by DSS，which suggests that it has a certain therapeutic effects on rats with UC. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
