世界中医药
降逆清热化浊方对非糜烂性胃食管反流病大鼠模型食管组织降钙素基因相关肽的影响
Study of Effects on Jiangni Qingre Huazhuo Prescription on Calcitonin Gene Related Peptide in Rats with Non-erosive Gastroesophageal Reflux Disease
投稿时间:2018-12-20  
DOI:10.3969/j.issn.1673-7202.2019.03.019
中文关键词:  胃食管反流;降逆清热化浊方;食管高敏感性  大鼠  降钙素基因相关肽;上皮细胞
英文关键词:Gastroesophageal reflux  Jiangni Qingre Huazhuo Prescription  Esophageal hypersensitivity  Rats  Calcitonin gene related peptide  Epithelial cells
基金项目:基金项目:第四批全国中医(临床、基础)优秀人才研修项目(国中医药人教发[2017]24号);北京市卫生系统高层次卫生技术人才培养计划(2015-3-114);北京中医医院-北京中医医院顺义医院两院合作科研项目(SYYJ201502)
作者单位
邱新萍1,陈瑞琳2,3,周滔2,李长新1,牛柯敏1,杨仲婷2,3,殷秀雯2,3,马万千1 1 北京中医医院顺义医院北京101300 2 首都医科大学附属北京中医医院北京100010 3 北京中医药大学北京100029 
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中文摘要:
      目的:观察降逆清热化浊方对非糜烂性胃食管反流病(NERD)大鼠模型食管组织降钙素基因相关肽(CGRP)的影响。方法:选取SD雄性大鼠60只并将其分为正常组、模型组、西药组和中药组。以鸡卵清蛋白/氢氧化铝基础致敏联合食管酸灌注的方法制备NERD大鼠模型,药物干预14 d后,观察各组大鼠食管组织的病理改变及高敏感性相关信号分子CGRP的表达情况。结果:与正常组比较,模型组大鼠食管组织上皮细胞间隙增宽,有少量炎性细胞;与模型组比较,中药组、西药组大鼠食管组织CGRP表达明显降低,且中药组降低更为显著。结论:降逆清热化浊方通过抑制CGRP的表达,下调食管高敏感性,从而对NERD起到治疗作用。
英文摘要:
      To observe the effects of Jiangni Qingre Huazhuo Prescription on the esophageal tissue CGRP in rats with non-erosive gastroesophageal reflux disease(NERD). Methods:Sixty male SD rats were divided into the normal group,model group,western medicine group and Chinese medicine group. The NERD rat model was prepared by chicken ovalbumin/aluminum hydroxide sensitization combined with esophageal acid perfusion. After 14 days of drug intervention,the pathological changes of esophageal tissue and the calcitonin gene related peptide(CGRP)of high-sensitivity-related signaling molecule was observed. Results:Compared with the normal group,the esophageal tissue epithelial cells in the model group were widened and a small amount of inflammatory cells were present. Compared with the model group,the expression of CGRP in the esophageal tissue of the rats in the Chinese medicine group and the western medicine group was significantly reduced. The decreased range of Chinese medicine group was more significant than that of the western medicine group. Conclusion:Jiangni Qingre Huazhuo Prescription can get therapeutic effects of non-erosive gastroesophageal reflux disease by inhibiting expression of CGRP and down-regulate the high sensitivity of esophagus.
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