| 引用本文:余玲，宋秋艳，甄月巧，董瑞鸿.血塞通联合甲钴胺和硫辛酸治疗DPN的临床疗效及其对血脂水平及血液流变学的影响[J].世界中医药,2019,(03):. |
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| 血塞通联合甲钴胺和硫辛酸治疗DPN的临床疗效及其对血脂水平及血液流变学的影响 |
| Clinical Effects of Xuesaitong Combined with Mecobalamine，Thioctic Acid in the Treatment of DPN and the Influence on the Level of Blood Lipid and the Blood Rheology |
| 投稿时间：2018-10-29 |
| DOI：10.3969/j.issn.1673-7202.2019.03.033 |
| 中文关键词: 血塞通注射液 硫辛酸 甲钴胺 糖尿病周围神经病变 神经传导速度 血脂水平 血液流变学 血糖 |
| English Keywords:Xuesaitong Injection Thioctic acid Mecobalamine Diabetic peripheraneuropathy Nerve conduction velocity Blood lipid Blood rheology Blood glucose |
| 基金项目:河南省卫生厅资助项目(201102007) |
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| 中文摘要: |
| 目的:观察血塞通联合甲钴胺和硫辛酸治疗糖尿病周围神经病变(DPN)的临床疗效及其对神经传导速度、血脂水平及血液流变学的影响。方法:选取2016年6月至2017年6月郑州大学第五附属医院收治的DPN患者144例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组72例。对照组在常规治疗的基础上给予硫辛酸和甲钴胺,观察组在对照组治疗的基础上给予血塞通注射液,观察2组患者治疗后的临床效果及FBG、2 hPG、HbA1C、感觉及运动神经传导速度、血脂水平(TC、TG、LDL-C、HDL-C)、血液流变学指标变化情况。结果:治疗后,2组FBG、2 hPG、HbA1C均有所降低,但差异无统计学意义(P>0.05)。2组治疗后FBG、2 hPG、HbA1C比较,差异无统计学意义(P>0.05)。与治疗前比较,2组治疗后TC、TG、LDL-C、红细胞压积、全血黏度高切、全血黏度低切、血浆黏度水平明显降低,HDL-C水平明显升高;观察组治疗后HDL-C水平明显高于对照组治疗后水平(P<0.05),TC、TG、LDL-C、红细胞压积、全血黏度高切、全血黏度低切、血浆黏度水平明显低于对照组治疗后水平(P<0.05)。与治疗前比较,2组治疗后感觉和运动神经传导速度明显加快;观察组治疗后感觉和运动神经传导速度明显高于对照组治疗后水平(P<0.05)。观察组治疗后的总有效率(90.28%)明显高于对照组(72.22%),差异有统计学意义(P<0.05)。结论:血塞通注射液联合甲钴胺和硫辛酸治疗DPN具有降低血脂水平,改善血液流变学,提高感觉及运动神经传导速度,从而提高临床治疗效果。 |
| English Summary: |
| To observe the clinical effects of Xuesaitongcombined with mecobalamine，thioctic acid in the treatment of diabetic peripheraneuropathy and the influence on the nerve conduction velocity，the level of blood lipid and the blood rheology. Methods:A total of 144 cases of diabetic peripheral neuropathy patients in Fifth Affiliated Hospital of Zhengzhou University from June 2016 to June 2017 were selected as research object and divided into the control group and the observation group according to random number table method，with 72 cases of each group. The control group was given mecobalamine and thioctic acid on the basis of routine therapy，while the observation group was given Xuesaitong Injection based on the treatment of the control group. The clinical effects，FBG，2 hPG，HbA1C，sensory and motor nerve conduction velocity，the level of blood lipid(TC，TG，LDL-C，HDL-C)，the index of hemorheology were observed of the 2 groups. Results:After treatment，the level of FBG，2HPG，HbA1C decreased，but the difference was not statistically significant(P>0.05). Compared with before treatment，the level of TC，TG，LDL-C，red blood cells deposited，whole blood high shear viscosity，whole blood low shear viscosity，plasma viscosity decreased significantly of the 2 groups. The level of HDL-C increased significantly. The level of HDL-C of the observational group was higher than the control group after treatment(P<0.05). TC，TG，LDL-C，red blood cells deposited，whole blood high shear viscosity，whole blood low shear viscosity，plasma viscosity were significantly decreased than the control group after treatment(P<0.05). Compared with before treatment，the sensory and motor nerve conduction velocity of the 2 groups quickened significantly after treatment. The sensory and motor nerve conduction velocity of the observation group were significantly higher than the level of the control group after treatment(P<0.05). The total effective rate of observation group after treatment(90.28%)was significantly higher than that of the control group(72.22%)，and the difference was statistically significant(P<0.05). Conclusion:Xuesaitong Injection combined with mecobalamine，thioctic acid in the treatment of diabetic peripheraneuropathy can reduce the level of blood fat，improve blood rheology and improve the sensory and motor nerve conduction velocity，so as to improve clinical therapeutic effects. |
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