| 引用本文:马浩哲1，黄奎2.补肾活血方对肾虚血瘀证膝关节骨性关节炎患者的疗效及其对血清细胞因子的影响[J].世界中医药,2019,(03):. |
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| 补肾活血方对肾虚血瘀证膝关节骨性关节炎患者的疗效及其对血清细胞因子的影响 |
| Effects of Bushen Huoxue Recipe on Knee Osteoarthritis Patients with Kidney Deficiency and Blood Stasis Syndrome and Its Influence on Serum Cytokines |
| 投稿时间：2018-05-08 |
| DOI：10.3969/j.issn.1673-7202.2019.03.035 |
| 中文关键词: 补肾活血方 肾虚血瘀证 膝关节骨性关节炎 中医症状总积分 视觉模拟评分 WOMAC总评分 Michel Lequesen指数评分 细胞因子 |
| English Keywords:Bushen Huoxue recipe Kidney deficiency and blood stasis syndrome Knee osteoarthritis Total score of TCM symptoms Visual analogue score WOMAC total score Michel Lequesen index score Cytokines |
| 基金项目:湖北省卫生计生委科研项目（2013zz108） |
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| 目的：研究补肾活血方对肾虚血瘀证膝关节骨性关节炎（KOA）患者的疗效及其对血清细胞因子的影响。方法：选取2016年2月至2017年11月荆州市第一人民医院收治的肾虚血瘀证KOA患者262例作为研究对象,按照随机数字表法将患者分为对照组和观察组，每组131例。对照组给予硫酸氨基葡萄糖胶囊以及塞来昔布胶囊治疗，观察组给予补肾活血方治疗，2组均治疗8周，观察2组临床疗效及不良反应，比较2组治疗前后中医症状总积分、视觉模拟评分（VAS）、WOMAC总评分、Michel Lequesen指数评分、血清细胞因子水平。结果：观察组总有效率为97.71%，高于对照组的89.31%（P<0.05）。2组治疗后中医症状总积分、VAS、WOMAC总评分、Michel Lequesen指数评分、丙二醛（MDA）、白细胞介素-1（IL-1）、白细胞介素-6（IL-6）水平均明显低于治疗前（P<0.05），且观察组较对照组更低（P<0.05）。2组治疗后超氧化物歧化酶（SOD）、转化生长因子-β（TGF-β）、成纤维细胞生长因子-2（FGF-2）水平明显高于治疗前，且观察组较对照组更高（P<0.05）。观察组不良反应发生率为0.76%，低于对照组的6.87%（P<0.05）。结论：补肾活血方治疗肾虚血瘀证KOA患者疗效显著，可改善患者临床症状及体征，降低炎性反应因子水平，且不良反应小。 |
| English Summary: |
| To study the effects of Bushen Huoxue recipe on knee osteoarthritis(KOA)patients with kidney deficiency and blood stasis and its influence on serum cytokines. Methods:A total of 262 KOA patients with kidney deficiency and blood stasis who were treated in the first people's Hospital of Jingzhou from February 2016 to November 2017 were selected. These patients were divided into the control group(n=131)and the observation group(n=131)according to random number table method. The control group was treated with glucosamine sulfate capsule and celecoxib capsule，while the observation group was treated with Bushen Huoxue recipe and the 2 groups were treated for 8 weeks. The clinical effects and adverse reactions of the 2 groups were observed. The total score of TCM symptoms，visual analogue score(VAS)，WOMAC total score，Michel Lequesen index score and serum cytokine levels of the 2 groups before and after the treatment were compared. Results:The total effective rate of the observation group was 97.71%，which was higher than 89.31% of the control group(P<0.05). After treatment the total score of TCM symptoms，VAS score，WOMAC total score，Michel Lequesen index score and the levels of malondialdehyde(MDA)，interleukin-1(IL-1)and interleukin-6(IL-6)in the 2 groups were significantly lower than before. Those of the observation group was lower than that of the control group(P<0.05). After treatment，the levels of superoxide dismutase(SOD)，transforming growth factor-β(TGF-β)and fibroblast growth factor-2(FGF-2)in the 2 groups were significantly higher than before. Those of the observation group was higher than that of the control group(P<0.05). The incidence of adverse reactions in the observation group was 0.76%，which was lower than 6.87% of control group(P<0.05). Conclusion:Bushen Huoxue recipe has significant effects on KOA patients with kidney deficiency and blood stasis syndrome，which can improve the clinical symptoms and signs，reduce the level of inflammatory factors. Furthermore，it has little toxic side effects. |
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