世界中医药

目的:比较便通胶囊与麻仁润肠丸治疗神经外科术后便秘的临床疗效及安全性。方法：选取2014年1月至2016年12月西安交通大学第一附属医院由治的神经外科术后患者192例作为研究对象，采用随机对照设计，随机分为观察组和对照组，每组96例。观察组服用便通胶囊，3粒/次，2次/d；对照组服用麻仁润肠丸，1～2丸/次，2次/d。2组疗程均为2周。记录2组患者术后72 h便秘发生率，术后3 d引流量，住院时间与首次排便时间，术后第1、3、7天免疫功能水平变化，术后并发症及不良反应等。结果:观察组术后72 h便秘发生率为2.01%，显著低于对照组的9.38%,2组间比较差异有统计学意义（P<0.05）；术后第1天引流量组间比较，差异无统计学意义（P>0.05），但术后第2、3天观察组引流量均低于对照组，差异有统计学意义（P<0.05）。观察组住院时间、置管时间与首次排便时间均短于对照组，各项指标组间差异有统计学意义（P<0.05）；2组免疫功能变化情况、术后并发症和不良反应情况，观察组疗效均优于对照组，组间差异有统计学意义（P<0.05）。结论:便通胶囊对神经外科术后便秘有显著治疗作用，对免疫功能有一定调节作用，疗效优于麻仁润肠丸，临床使用安全性高。

English Summary:

To compare the efficacy and safety of BianTong Capsule and Maren Runchang Pill in treating constipation after neurosurgery. Methods:A total of 192 patients undergoing neurosurgery in the First Affiliated Hospital of Xi'an Jiaotong University from January 2014 to December 2016 were enrolled in the randomized controlled trial. They were randomly divided into the observation group and the control group，with 96 in each group. The observation group took Biantong capsule，3 capsules a day，2 times a day for 2 weeks，and the control group took Maren Runchang Pills，1 to 2 pills a day，2 times a day，for 2 weeks. The incidence of constipation at 72 hours after operation，the drainage volume at 3 days postoperatively，the length of hospital stay and the first defecation time，the changes of immune function at the 1st，3rd，and 7th postoperative days，and postoperative complications were recorded. Results:The incidence of constipation at the 72 h postoperatively was 2.01% in the observation group，which was significantly lower than 9.38% in the control group 9.38%. The difference between the two groups was statistically significant(P<0.05). There was no difference in drainage volume between the 2 groups on the first day after operation(P>0.05)，but the drainage volume of the observation group was lower than that of the control group on the second and third day after operation(P<0.05). The hospitalization time，drainage tube indwelling time and the first defecation time were shorter in the observation group than in the control group. The difference between the groups was statistically significant(P<0.05); the change of immune function level and postoperative complications and the adverse reactions of the 2 groups were better than the control group. There were statistically significant differences between the groups(P<0.05). Conclusion:Biantong Capsule has significant therapeutic effects on constipation after neurosurgery，and has certain regulation effects on immune function. The curative effect is better than that of Maren Runchang Pill. It has high clinical safety and is worthy of clinical application.

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