| 引用本文:郑思道，曹春，姚全.人参皂苷调控转化生长因子-β信号通路的作用机制[J].世界中医药,2019,(03):. |
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| 人参皂苷调控转化生长因子-β信号通路的作用机制 |
| Regulatory Effects of Ginsenosides on Transforming Growth Factor β Signal Pathway |
| 投稿时间：2016-10-29 |
| DOI：10.3969/j.issn.1673-7202.2019.03.051 |
| 中文关键词: 人参 人参皂苷 转化生长因子-β 信号通路 |
| English Keywords:Ginseng Ginsenoside TGF-β Signal transduction pathway |
| 基金项目:北京市优秀人才培养资助青年骨干个人项目（2014000057592G296） |
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| 中文摘要: |
| 2000多年前,人参就被东亚各国视为珍贵药材，用于防治心血管、中枢神经系统、糖尿病、肿瘤和免疫疾病等相关疾病的现代药理作用被逐渐证实，前述药理作用的基础在于以人参皂苷为代表的活性成分。转化生长因子-β可以调节细胞生长、分化、凋亡、侵袭、细胞外基质合成、血管生成、免疫等多种病理生理过程，是药物治疗的重要靶点。目前研究显示，由转化生长因子-β介导的人参药效作用主要表现为对免疫的调节、对中枢神经的保护、对糖尿病及并发症的治疗、对肿瘤的抑制等方面。相关研究从现代药理机制阐释了人参及其主要活性成分的药效特点，具有较一致的研究结论。部分人参皂苷对不同组织转化生长因子-β的调控作用存在相反结果，提示其治疗作用的组织特异性，也可能是中药双向调节理论的又一个例证。通过阐述经由转化生长因子-β信号通路介导的人参皂苷药理作用，不仅能够促进探索传统中药的现代药理机制，利于现代医学和更多地区理解、接受传统药物，也可以在传统药物活性成分基础上研发新药物，同时在一定程度上促进传统中医药理论的发展。 |
| English Summary: |
| The root of Panax ginseng C. A. Mayer，named Ginseng，had been used as one of valuable medicinal herbs in East Asia approximately 2000 years ago. Recent evidence has shown that Ginseng is effective in preventing and reversing different types of diseases，such as cardiovascular diseases，central nervous system disorders，diabetes mellitus，tumors，immunity diseases. Moreover，several important active ingredients had been found，in which ginsenoside predominates. Transforming growth factor beta(TGF-β)are potent regulators of multiple cellular functions，including cell growth，differentiation，apoptosis，migration，excessive extracellular matrix production and immunity，which is a critical target spot in the treatment of diseases. Current studies have revealed that Ginseng's therapeutic effects mentioned above are induced mainly by ginsenoside and its regulation on TGF-β signaling pathways. Gisengside has multiple regulating effects on TGF-β signaling pathways，and elucidation of the mechanisms is progressing. The same ginsenoside could regulate TGF-β signaling pathways in directions that are completely contrary to each other between different tissues，indicating the fact that gisengside regulates TGF-β signaling pathways in a tissue‐specific manner，confirming the bi-directional regulating theory of Chinese medicinal herbs. The studies of gisengside on TGF-β signaling pathways not only alleviate the exploration of the pharmacological mechanism of Chinese medicinal herbs，but also facilitate understanding and accept traditional medical herbs for modern medicine and western people. All such studies would provide evidence for gisengside's clinical application and drug discovery. |
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