| 引用本文:汪宁，温昌明，张保朝.中西医结合对急性心源性脑梗死患者血清PLG和神经功能的影响[J].世界中医药,2019,(04):. |
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| 中西医结合对急性心源性脑梗死患者血清PLG和神经功能的影响 |
| Effects of Integration of Traditional Chinese and Western Medicine on Serum PLG and Neurological Function in Patients with Acute Cardiogenic Cerebral Embolism |
| 投稿时间：2018-12-05 |
| DOI：10.3969/j.issn.1673-7202.2019.04.021 |
| 中文关键词: 急性心源性脑梗死 纤溶酶原 血流变 神经功能 马来酸桂哌齐特 消栓宁心汤 |
| English Keywords:Acute cardiogenic cerebral embolism PLG Blood rheology Neurological function Cinepazide maleate Xiaoshuan Ningxin decoction |
| 基金项目:国家科学技术部重点研发计划项目（2018YFC1002203） |
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| 中文摘要: |
| 目的:探讨中西医结合对急性心源性脑梗死(ACCE)患者血清纤溶酶原(PLG)和神经功能的影响。方法:选取2016年4月至2018年4月南阳市中心医院收治的ACCE患者98例作为研究对象,随机分为对照组和观察组,每组49例。对照组给予马来酸桂哌齐特,观察组给予马来酸桂哌齐特联合消栓宁心汤。观察和比较2组患者的纤溶指标、血流变、神经功能和疗效。结果:治疗后,2组患者的血清PLG、人凝血因子Ⅷ相关抗原(VWF-Ag)和血栓素B2(TXB2)显著降低,6-酮-前列腺素F1α(6-kcto-PGF1α)显著升高,且观察组患者的血清PLG、VWF-Ag、TXB2显著低于对照组,6-kcto-PGF1α显著高于对照组(P<0.05);观察组患者的血浆黏度、全血黏度显著低于对照组,粥样斑块减小面积显著高于对照组,2组比较差异有统计学意义(P<0.05);2组患者的NIHSS评分均降低,且观察组显著低于对照组,差异有统计学意义(P<0.05);观察组的总有效率(95.91%)显著高于对照组的总有效率(71.42%),差异有统计学意义(P<0.05)。结论:消栓宁心汤联合西药能有效改善ACCE患者体内的纤溶系统活性,降低血液黏度,减轻患者神经功能缺损,具有显著的临床疗效。 |
| English Summary: |
| To explore the effects on serum PLG and neurological function in patients with acute cardiogenic cerebral embolism (ACCE) using integration of traditional Chinese and western medicine.Methods:A total of 98 patients with ACCE treated in Nanyang Central Hospital from April 2016 to April 2018 were randomly divided into the control group (49 cases) and the observation group (49 cases).The control group was given cinepazide maleate，and the observation group was given Xiaoshuan Ningxin decoction combined with cinepazide maleate.The fibrinolytic indexes，blood rheology，neurological function and curative effect were observed and compared between the 2 groups.Results:After treatment，the serum levels of PLG，VWF-Ag and TXB2 in the 2 groups were significantly decreased，while the serum levels of 6-kcto-PGF1α significantly increased，and the changes in the observation group were more significant than those in the control group (P<0.05).The plasma viscosity and total blood viscosity in the observation group were lower than those in the control group，and the reduced area of atheromatous plaque was higher than that in the control group (P<0.05).The scores of NIHSS in both groups decreased，and the score of NIHSS in the observation group was significantly lower than that in the control group (P<0.05).The total effective rate in the treatment group was higher than that in the control group (95.91% vs 71.42%，P<0.05).Conclusion:Xiaoshuan Ningxin decoction combined with western medicine can effectively improve the fibrinolytic system activity，reduce blood viscosity，and alleviate the neurological function defect in patients with ACCE，which has significant clinical effects. |
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