| 引用本文:赵丽1，胡小凤2，许邦丽2.中药熏蒸联合人工泪液治疗干眼症的临床观察及对患者视觉相关生命质量的影响[J].世界中医药,2019,(04):. |
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| 中药熏蒸联合人工泪液治疗干眼症的临床观察及对患者视觉相关生命质量的影响 |
| Clinical Observation on Chinese Medicine Fumigation Combined with Artificial Tear in the Treatment of Dry Eye and the Effects on the Vision-related Life Quality |
| 投稿时间：2018-11-06 |
| DOI：10.3969/j.issn.1673-7202.2019.04.023 |
| 中文关键词: 干眼症 人工泪液 中药 熏蒸 视觉相关 生命质量 |
| English Keywords:Dry eye Artificial tear Chinese medicine Fumigation Vision-related Life quality |
| 基金项目:国家自然科学基金项目（81102214） |
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| 中文摘要: |
| 目的：探究中药熏蒸联合人工泪液治疗干眼症的临床疗效，分析其对患者视觉相关生命质量的影响。方法：选取2014年11月至2016年12月北京市健宫医院收治的干眼症患者72例作为研究对象，按照随机数字表法随机分为对照组和观察组，每组36例（72只患眼），对照组给予人工泪液治疗，观察组在对照组的基础上联合中药熏蒸治疗，2周为1个疗程，2组均连续治疗2个疗程。统计2组临床疗效；比较2组患者治疗前后主要中医症状积分、泪液分泌量、泪膜破裂时间；采用美国国家眼科研究所视觉相关生命质量量表（NEI-VFQ-25）评价并比较2组患者治疗前后视觉相关生命质量。结果：治疗后观察组总有效率为90.28%，较对照组的63.89%显著升高（P<0.01）；与治疗前比较，治疗后2组患者患眼疲劳感、干涩感、异物感及烧灼感等症状积分均显著降低，且观察组显著低于对照组（P<0.01）；与治疗前比较，治疗2周后至治疗4周后2组泪液分泌量呈逐渐升高趋势（P<0.01），泪膜破裂时间呈逐渐延长趋势（P<0.05），且治疗后2组间差异有统计学意义（P<0.05或P<0.01）；与治疗前比较，治疗后2组患眼一般健康状况、活动障碍及视力障碍评分均显著升高（P<0.01），且观察组显著高于对照组（P<0.01）。结论：中药熏蒸联合人工泪液治疗干眼症可有效缓解患眼临床症状，促进患眼泪液分泌并增强泪膜稳定性，同时还可显著改善患眼视觉相关生命质量，疗效显著优于人工泪液单用。 |
| English Summary: |
| To explore the clinical efficacy of Chinese medicine fumigation combined with artificial tear in the treatment of dry eye，and analyze the effects on the vision-related life quality.Methods:A total of 72 cases patients with dry eye treated in Beijing Jiangong Hospital from November 2014 to December 2016 were divided randomly into the control group(n＝36，72 cases eyes）and the observation group(n＝36，72 cases eyes）according to random number table.The control group was treated with artificial tear，and the observation group was treated with Chinese medicine fumigation on the basis of control group，2 weeks as 1 course，and 2 groups were treated for 2 courses.The clinical efficacy of 2 groups were statisticsed; the main Chinese medicine symptom integrals of 2 groups before and after treatment were evaluated and compared; the lacrimal secretion and breakup time of tear film in 2 groups before and after treatment were detected and compared; the vision-related life quality of 2 groups before and after treatment were evaluated and compared by the U.S.national eye institute visual related quality of life scale-25(NEI-VFQ-25).Results:The total effective rate of study group was 90.28%，which was higher than that 63.89% of control group(P<0.01); Compared with before treatment，the symptoms integrals of fatigue feeling，dry feeling，foreign body sensation and burning sensation decreased significantly，and the observation group was lower than control group; Compared with before treatment，the lacrimal secretion showed a trend of increasing gradually from 2 to 4 weeks after treatment(P<0.01)，and the breakup time of tear film showed a trend of decreasing gradually(P<0.05)，and the difference between the 2 groups after treatment was significant(P<0.05 or P<0.01); Compared with before treatment，the scores of general health，movement disorder and visual impairment of eyes in 2 groups after treatment increased significantly(P<0.01)，and the observation group was higher than control group(P<0.01).Conclusion:Chinese medicine fumigation combined with artificial tear can remit the clinical syndromes of patients with dry eye，promote the tear secretion and enhance the tear film stability effectively，and which can improve the vision-related life quality of eyes.The clinical efficacy is better than artificial tear alone. |
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