世界中医药

目的:探讨真武汤对老年慢性心力衰竭患者血流动力学、基质金属蛋白酶-9(MMP-9)和心功能的影响。方法:选取2016年3月至2018年2月武汉大学人民医院收治的老年慢性心力衰竭患者88例作为研究对象,随机分为对照组和观察组,每组44例。对照组采用常规西药治疗,观察组在此基础上口服真武汤治疗。比较治疗前后2组患者的血流动力学、心功能、MMP-9,基质金属蛋白酶抑制剂(TIMP-1)和疗效。结果:观察组总有效率为93.18%,高于对照组总有效率(72.73%,P<0.05)。治疗后与治疗前比较,2组外周阻力、外周阻力指数、左室收末内径(LVESD)、N端前脑钠肽(NT-proBNP)和MMP-9均降低(P<0.05);加速指数、心排量、心排指数、每搏输出量、左心室舒张末期内径(LVEDD)、左室射血分数(LVEF)和TIMP-1均升高(P<0.05),且观察组上述指标的改变较对照组更为显著,差异有统计学意义(P<0.05)。结论:在常规西药治疗下,真武汤有效改善患者心功能,恢复心脏正常重构,提高心脏供血能力,疗效确切。

English Summary:

To explore the effects on hemodynamics，MMP-9 and cardiac function in elderly patients with chronic heart failure using Zhenwu Decoction.Methods:A total of 88 elderly patients with chronic heart failure admitted into Remin Hospital of Wuhan University from March 2016 to February 2018 were randomly divided into the observation group (44 cases) and the control group (44 cases).The control group was treated with conventional western medicine，and the observation group was added Zhenwu Decoction.Hemodynamics，cardiac function，the levels of MMP-9，TIMP-1 and curative effects were compared between the 2 groups before and after treatment.Results:The total effective rate in the observation group was 93.18%，which was higher than that in the control group (72.73%，P<0.05).After treatment，peripheral resistance，peripheral resistance index，LVESD，the levels of NT-proBNP and MMP-9 in the 2 groups all decreased (P<0.05)，and acceleration index，cardiac output index，cardiac output index，output per stroke，LVEDD，LVEF and the levels of TIMP-1all increased (P<0.05).The above changes in the observation group was more significant than those in the control group，and the difference was statistically significant (P<0.05).Conclusion:Under the conventional western medicine treatment，Zhenwu Decoction can effectively improve the cardiac function，restore the normal reconstruction of the heart，and improve the blood supply ability of the heart，with certain curative efficacy.

查看全文查看/发表评论下载PDF阅读器