| 引用本文:邓开智，冷明敏，唐建.马应龙麝香痔疮膏联合地奥司明片对混合痔术后创面水肿的防治效果[J].世界中医药,2019,(04):. |
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| 马应龙麝香痔疮膏联合地奥司明片对混合痔术后创面水肿的防治效果 |
| Prevention and Curative Effect of Mayinglong Shexiang Haemorrhoids Creams Combined with Diosmin Tablets on Wound Edema of Mixed Hemorrhoids after Operation |
| 投稿时间：2018-12-05 |
| DOI：10.3969/j.issn.1673-7202.2019.04.033 |
| 中文关键词: 混合痔 马应龙麝香痔疮膏 地奥司明 水肿 疼痛 P物质 疗效 创面 |
| English Keywords:Mixed hemorrhoids Mayinglong Shexiang Haemorrhoids Creams Diosmin Edema Pain Substance P Curative effect Wounds |
| 基金项目:四川省德阳市科委计划项目（2014SZ040） |
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| 中文摘要: |
| 目的:探讨马应龙麝香痔疮膏联合地奥司明片对混合痔术后创面水肿的防治效果。方法:选取2015年10月至2017年10月德阳市人民医院收治的混合痔术后患者144例作为研究对象,随机分为对照组和观察组,每组72例。对照组患者给予迈之灵片口服治疗,观察组给予地奥司明片口服,马应龙麝香痔疮膏涂抹于肛门创面附近,2组均连续治疗7 d,随访6个月。比较2组患者临床疗效,评估2组患者术后创面疼痛、水肿恢复情况、肛门功能,检测并比较2组创面P物质(SP)含量。结果:治疗后观察组总有效率为95.83%显著高于对照组的79.17%(P<0.01)。术后2~6 d,2组创面NRS评分和水肿评分逐渐降低(P<0.01),且术后4 d、6 d观察组创面NRS评分和水肿评分低于对照组,疼痛和水肿缓解时间较对照组缩短(P<0.01)。从出院至术后6个月,2组Wexner评分逐渐降低(P<0.01),观察组出院时Wexner评分低于对照组(P<0.01),术后3~6个月2组Wexner评分差异无统计学意义(P>0.05)。术后2~6 d,2组创面SP含量呈现逐渐升高趋势(P<0.01),且观察组术后4 d、6 d创面SP含量明显高于对照组(P<0.01)。结论:混合痔术后患者应用马应龙麝香痔疮膏联合地奥司明片治疗可加速创面疼痛及水肿的缓解,改善患者肛门功能,可能与增加创面组织中SP含量有关。 |
| English Summary: |
| To explore the prevention and curative effect of Mayinglong Shexiang Haemorrhoids Creams joint diosmin tablets on wound edema of mixed hemorrhoids after operation.Methods:A total of 144 cases of mixed hemorrhoids patients after operation in Deyang People's Hospital from October 2015 to October 2017 were selected as the research objects and randomly divided into the observation group (72 cases) and the control group (72 cases).The patients in the control group were given oral administration of Maizhiling tablets，and the observation group was given diosmin tablets orally.Mayinglong Shexiang Haemorrhoids Creams was smeared near the anal wound.The 2 groups were treated for 7 d and followed-up for 6 months.The clinical efficacy of the 2 groups were statistically analyzed，and wound pain and edema recovery，anal function in the 2 groups were evaluated.The content of wounds substance P (SP) in the 2 groups were detected and compared.Results:The total effective rate was 95.83% in the observation group after treatment，which was significantly higher than 79.17% in the control group (P<0.01).At 2 d to 6 d after operation，the NRS score and edema score of the 2 groups decreased gradually (P<0.01).At 4 d and 6 d after operation，the NRS score and edema score in the observation group were lower than those in the control group，and the remission time of pain and edema were shorter than those in the control group (P<0.01).From discharge to 6 months after operation，the Wexner score in the 2 groups gradually reduced (P<0.01)，and the Wexner score of the observation group at discharge was lower than that of the control group (P<0.01)，and there was no significant difference in the Wexner score of 3-6 months after operation between the 2 groups (P>0.05).At 2 d to 6 d after operation，the wound SP content in the 2 groups increased gradually (P<0.01)，and the SP content of 2～4 d after operation in the observation group were significantly higher than those in the control group (P<0.01).Conclusion:Mayinglong Shexiang Haemorrhoids Creams joint diosmin tablets in the treatment of postoperative mixed hemorrhoids patients can accelerate the relief of wound pain and edema，improve the anal function，which may be related to the promotion of SP expression in the wound tissue. |
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