| 引用本文:赵吟，邓彧斐.热毒宁注射液对儿童急性喉气管炎免疫功能及炎性反应的影响[J].世界中医药,2019,(04):. |
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| 热毒宁注射液对儿童急性喉气管炎免疫功能及炎性反应的影响 |
| Effects of Reduning injection on Immune Function and Inflammation in Children with Acute Laryngotracheitis |
| 投稿时间：2018-11-06 |
| DOI：10.3969/j.issn.1673-7202.2019.04.037 |
| 中文关键词: 热毒宁 小儿 急性喉气管炎 免疫功能 炎性因子 随机对照 |
| English Keywords:Reduning Children Acute laryngotracheitis Immune function Inflammatory factors Randomized control |
| 基金项目:无锡市科技发展指导性计划（医疗卫生）（CSZ0N1706） |
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| 中文摘要: |
| 目的：探讨热毒宁注射液对儿童急性喉气管炎患儿免疫功能及炎性反应状态的影响。方法：选取2016年5月至2018年5月无锡市第二人民医院收治的急性喉气管炎患儿50例作为研究对象，采用随机、单盲、平行对照法将患儿分为观察组和对照组，每组25例，2组患儿均给予常规治疗，观察组同时使用热毒宁注射液。2组均连续治疗5 d。观察并统计2组临床症状缓解时间及临床疗效，检测并比较2组免疫功能、炎性因子指标变化。结果：观察组临床治疗总有效率为96.00%，与对照组的76.00%比较，差异有统计学意义（P<0.05）。与对照组比较，治疗后观察组声音嘶鸣、犬吠样咳嗽及吸气性呼吸困难等症状消失时间明显缩短（P<0.05或P<0.01）。治疗后2组血清IgA、IgG水平较治疗前均显著升高，IgE水平显著降低，且观察组改善情况优于对照组（P<0.05或P<0.01）。与治疗前比较，治疗后2组患儿血清CysLTs、ECP水平均降低，且观察组患儿明显低于对照组（P<0.01）。结论：热毒宁注射液可显著缓解急性喉气管炎患儿临床症状，同时对患儿机体免疫功能及炎性反应状态的调控效果较西医常规治疗更为突出。 |
| English Summary: |
| To investigate the effects of Reduning injection on immune function and inflammatory state in children with acute laryngotracheitis.Methods:A total of 50 children with acute laryngotracheitis diagnosed in The Second People's Hospital of Wuxi from May 2016 to May 2018 were divided into the observation group(n＝25）and the control group(n＝25）by randomized，single-blind and parallel control method.Both groups were given routine treatment，and the observation group meanwhile was given Reduning injection.The 2 groups were treated continuously for 5 d.The remission of clinical symptoms and clinical efficacy of the 2 groups were observed and statistically analyzed.The changes of immune function and inflammatory factors were detected and compared between the 2 groups.Results:The total effective rate of the observation group was 96.00%，which was significantly higher than that of the control group(76.00%)(P<0.05).Compared with the control group，the disappearance time of voice hiss，barking cough and inspiratory dyspnea of the observation group were significantly shorter(P<0.05 or P<0.01).Compared with before treatment，the levels of serum IgA and IgG in the 2 groups after treatment were significantly higher，and the levels of serum IgE were lower.The improvement of the observation group was better than those of the control group(P<0.05 or P<0.01).Compared with before treatment，the levels of serum CysLTs and ECP in the 2 groups were lower after treatment，and the levels in the observation group were significantly lower than those in the control group(P<0.01).Conclusion:Reduning injection can significantly alleviate the clinical symptoms of children with acute laryngotracheitis，at the same time，the regulation of immune function and inflammatory state of children is more prominent than that of Western medicine. |
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